75869-37-3Relevant academic research and scientific papers
Sequential Continuous-Flow Synthesis of 3-Aryl Benzofuranones
Xin, Hai-Long,Rao, Xiaofeng,Ishitani, Haruro,Kobayashi, Shū
, p. 1906 - 1910 (2021/06/27)
A sequential continuous-flow system to produce 3-aryl benzofuranones was developed. Starting from 2,4-di-tert-butylphenol and glyoxylic acid monohydrate, both the initial cyclocondensation and the subsequent Friedel?Crafts alkylation were catalyzed by the same heterogeneous catalyst, Amberlyst-15H. The catalyst has a promising life-time for these two steps, and it was able to be recovered and reused for several runs without deactivation. By using the established flow system, 5,7-di-tert-butyl-3-(3,4-dimethylphenyl)-3H-benzofuran-2-one (Irganox HP-136), which is a commercial antioxidant, was prepared in 88% two-step yield. Reactions with various aromatic compounds proceeded well under flow conditions to afford 3-aryl benzo-furanone derivatives in high yields with good functional group compatibility.
A versatile new synthesis of 3-aryl-3H-benzofuran-2-ones
Nesvadba, Peter,Bugnon, Lucienne,Dubs, Paul,Evans, Samuel
, p. 863 - 864 (2007/10/03)
Aromatic or heteroaromatic hydrocarbons are easily alkylated with 3- hydroxy-3H-benzofuran-2-ones under Friedel-Crafts or acid catalysis to afford 3-aryl-3H-benzofuran-2-ones in good yield. Access to the starting 3-hydroxy- 3H-benzofuran-2-ones is easily achievable by reaction of suitably substituted phenols with glyoxylic acid.
