758705-70-3

Basic information

• Product Name: 2-Chloro-6-Methoxypurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside
• Synonyms: 2-Chloro-6-Methoxypurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside;2-Chloro-6-Methoxy-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine;2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-6-methoxy-9H-purine;2-CHLORO-6-METHOXY-9-(2-DEOXY-2-FLUORO-BETA-D-ARABINOFURANOSYL)-9H-PURINE
• CAS NO: 758705-70-3
• Molecular Formula: C11H12ClFN4O4
• Molecular Weight: 318.6887832
• Mol File: 758705-70-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Chloro-6-Methoxypurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-Methoxypurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside(758705-70-3)
• EPA Substance Registry System: 2-Chloro-6-Methoxypurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside(758705-70-3)

Safety Data

• Hazardous Substances Data: 758705-70-3(Hazardous Substances Data)

Upstream product

• 124-41-4 sodium methylate 
• 329187-80-6 ((2R,3R,4S,5R)-3-(benzoyloxy)-5-(2,6-dichloro-9H-purin-9-yl)-4-fluorotetrahydrofuran-2-yl)methyl benzoate 

Relevant articles and documents

Synthesis and anti-HIV activity of 2′-fluorine modified nucleoside phosphonates: Analogs of GS-9148

Modified purine analogs of GS-9148 [5-(6-amino-purin-9-yl)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl]-phosphonic acid (2′-Fd4AP) were synthesized and their anti-HIV potency evaluated. The antiviral activity of guanosine analog (2′-Fd4GP) was comparable that of to 2′-Fd4AP in MT-2 cells, but selectivity was reduced.