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Usage

Uses

Used in Pharmaceutical Industry:
1-ADAMANTAN-1-YL-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE is used as a building block for the synthesis of various pharmaceuticals. Its unique structure and reactivity allow for the creation of a wide range of medicinal compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-ADAMANTAN-1-YL-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE serves as a key intermediate in the development of new agrochemicals. Its incorporation into these products can enhance their effectiveness and selectivity in agricultural applications.
Used in Chemical Research and Development:
1-ADAMANTAN-1-YL-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE is employed as a reagent in the preparation of other fluorine-containing compounds. Its versatility in undergoing various chemical reactions makes it a valuable asset in the field of chemical research and development, contributing to the discovery of novel compounds and materials.

Upstream product

• 407-38-5 2,2,2-trifluoroethyl trifluoroacetate 
• 1660-04-4 1-acetyladamantane 
• 383-63-1 ethyl trifluoroacetate, 

Relevant academic research and scientific papers

Synthesis and structure of bis[1-(1-adamantyl)-4,4,4-trifluorobutane-2,4- dionato]copper

Previously unknown 1-(1-adamantyl)-4,4,4-trifluorobutane-2,4-dione and its copper complex, bis [1-(1-adamantyl)-4,4,4-trifluorobutane-2,4-dionato]copper, were synthesized. The 1H NMR, IR, and ESR spectra and X-ray diffraction patterns of the sy

Exploiting the facile release of trifluoroacetate for the α-methylenation of the sterically hindered carbonyl groups on (+)-sclareolide and (-)-eburnamonine

An efficient method for the α-methylenation of carbonyl groups is reported, and this transformation is accomplished by a facile elimination of trifluoroacetate during the formation of the olefin. This method represents an improvement beyond existing protocol in cases of steric hindrance, and we have demonstrated the utility of the process across a series of ketones, lactams, and lactones. Additionally, we have applied this method to produce semisynthetic derivatives of the natural products (+)-sclareolide and (-)-eburnamonine, in which the carbonyl group is proximal to bulky functional groups. Mechanistic insight is also provided from a time course of 19F NMR. Biological evaluation of the natural-product-derived enones led to the identification of a derivative of (-)-eburnamonine with significant cytotoxicity (LC50 = 14.12 ?M) in drug-resistant MDA-MB-231 breast cancer cells.