75872-28-5Relevant academic research and scientific papers
Microwaves in organic synthesis: Facile synthesis of biologically active pyridazinone and iminopyridazine derivatives
Mohamed, Nadia Ragab,El-Saidi, Manal Mohamed Talaat,Ali, Yasser Mahmoud,Elnagdi, Mohamed Hilmy
, p. 1333 - 1337 (2008/09/18)
(Chemical Equation Presented) Condensation of Wittig reagents 1a,b with arylhydrazones 2a,b by conventional and by microwave heating techniques furnished the corresponding pyridazines 3a-e. The arylhydrazones 7a,b were allowed to react with 1a,b under the same conditions to produce the pyridazinones 10a,b and iminopyridazines 11a,b respectively. On the other hand, the arylhydrazones 12a-c reacted with 1a to afford the pyridazinones 13a-c. Treatment of 3b with dimethylformamide dimethyl acetal (DMFDMA) produced the adduct 15. The utility of microwave heating technique led to the reduction of the reaction times to few minutes and to the improvement of the yields of the products. The in vitro biological activity of some newly prepared compounds against four types of fungi was studied.
The Utility of Phosphonium Ylides in Heterocyclic Synthesis: Synthesis of Pyridazinone and tetrahydrocinnolinone Derivatives
Nada, Afaf Aly,Erian, Ayman Wahba,Mohamed, Nadia Ragab,Mahran, Asma Mohamed
, p. 1576 - 1594 (2007/10/03)
The synthesis of pyridazinone and tetrahydrocinnolinone derivatives via the reaction of phosphonium ylides with different hydrazones was accomplished.The reaction of Wittig reagents with a pyridazinone derivative was also achieved. - Keywords: phosphonium ylides; hydrazones; pyridazinones and tetrahydrocinnolinones
A new and convenient synthesis of 3(2H)-pyridazinones by reacting carbanion of ethyl trimethylsilylacetate with phenylhydrazones
Patel,Vyas,Pandey,Tavares,Fernandes
, p. 1935 - 1940 (2007/10/02)
A one-pot synthesis of 5,6-disubstituted-2-phenyl-3(2H)-pyridazinones 4 is achieved on treatment of carbanion of ethyl trimethylsilylacetate with phenylhydrazones of 1,2-dicarbonyl compounds 1.
Reaction of triethyl phosphonoacetate anion with phenylhydrazones: A new method for the preparation of 3(2H)-pyridazinones
Patel,Vyas,Pandey,Tavares,Fernandes
, p. 1021 - 1026 (2007/10/02)
Various 5,6-disubstituted-2-phenyl-3(2H)-pyridazinones 4 have been synthesised by reacting triethyl phosphonoacetate anion with monophenylhydrazone of 1,2-dicarbonyl compounds 2.
Cumulated Ylides, XIV - Phosphacumulene Ylides - Building Blocks for the Synthesis of Heterocyclic Compounds
Bestmann, Hans Juergen,Schmid, Guenter,Sandmeier, Dieter,Schade, Gerold,Oechsner, Helmut
, p. 1709 - 1719 (2007/10/02)
Phosphacumulene ylides 1 and acidic compounds 4 combine to give phosphoranes 5, which cyclize by an intramolecular reaction (mostly Wittig reaction) with formation of heterocycles 7.
Stickstoff- und Schwefelheterocyclen aus NH- und SH-aciden Carbonylverbindungen und Phosphacumulenyliden
Bestmann, Hans Juergen,Schmid, Guenter,Sandmeier, Dieter
, p. 2939 - 2942 (2007/10/02)
Phosphacumulenylide reagieren mit 1,2,3-Tricarbonyl-2-phenylhydrazonen zu Pyridazinderivaten, mit β-Ketoenaminen zu Pyridindionabkoemmlingen und mit α-Ketothiocarbonsaeureamiden zu Verbindungen der Dihydrothiophendion-Reihe.
