758720-54-6Relevant academic research and scientific papers
N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity
Schlapbach, Achim,Revesz, Laszlo,Pissot Soldermann, Carole,Zoller, Thomas,Régnier, Catherine H.,Bornancin, Frédéric,Radimerski, Thomas,Blank, Jutta,Schuffenhauer, Ansgar,Renatus, Martin,Erbel, Paulus,Melkko, Samu,Heng, Richard,Simic, Oliver,Endres, Ralf,Wartmann, Markus,Quancard, Jean
supporting information, p. 2153 - 2158 (2018/05/23)
Starting from a weak screening hit, potent and selective inhibitors of the MALT1 protease function were elaborated. Advanced compounds displayed high potency in biochemical and cellular assays. Compounds showed activity in a mechanistic Jurkat T cell acti
NOVEL HETEROCYCLIC DERIVATIVES AS M-GLU5 ANTAGONISTS
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Page/Page column 75, (2009/03/07)
This invention relates to novel heterocyclic compounds having selective affinity for the mGlu5 subtype of metabotropic receptors, pharmaceutical compositions thereof and uses for such compounds and compositions in the treatment of lower urinary tract diso
4-Piperidinecarboxamide modulators of vanilloid VR1 receptor
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Page/Page column 62, (2010/11/08)
This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals.
Substituted benzoylureidopyridylpiperidine-and-pyrrolidinecarboxylic acid derivatives, processes for preparing them and their use
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Page 7, (2008/06/13)
The invention relates to compounds of the formula I where the radicals are as defined, and their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.
