75889-54-2

Basic information

• Product Name: 8-METHOXY-2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBALDEHYDE
• Synonyms: 8-methoxy-2,3-dihydro-1,4-benzodioxine-6-carboxaldehyde;ST5137683;ZINC03882888;2,3-Dihydro-8-methoxy-benzo[b][1,4]dioxin-6-carbaldehyde;8-METHOXY-2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBALDEHYDE;8-METHOXY-2,3-DIHYDRO-BENZO[1,4]DIOXINE-6-CARBALDEHYDE;AKOS BBS-00004674;3-Methoxy-4,5-ethylenedioxybenzaldehyde
• CAS NO: 75889-54-2
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.18
• Mol File: 75889-54-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 8-METHOXY-2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-METHOXY-2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBALDEHYDE(75889-54-2)
• EPA Substance Registry System: 8-METHOXY-2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBALDEHYDE(75889-54-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 75889-54-2(Hazardous Substances Data)

Usage

General Description

8-METHOXY-2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBALDEHYDE, also known as MDB, is a chemical compound with the molecular formula C10H10O4. It is a derivative of the naturally occurring compound safrole, which is commonly found in certain essential oils. MDB is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals, as well as in the production of flavors and fragrances. It is also known to possess antibacterial and antifungal properties, and has been studied for its potential use in the treatment of certain medical conditions. However, it is important to note that MDB may pose health risks if not handled properly, and therefore should be used with caution and under the guidance of a trained professional.

Upstream product

• 2973-76-4 5-bromo-4-hydroxy-3-methoxybenzaldehyde 
• 3934-87-0 5-hydroxyvanillin 
• 106-93-4 ethylene dibromide 

Downstream Products

• 1449420-91-0 4-(4-methoxyphenyl)-5-(3-methoxy-4,5-ethylenedioxyphenyl)-1H-pyrazol-3-amine 
• 1427070-68-5 2-(4-methoxyphenyl)-3-oxo-3-(3-methoxy-4,5-ethylenedioxyphenyl)propanenitrile 
• 1257321-07-5 3,4'-dimethoxy-4,5-ethylenedioxy-3'-O-t-butyldimethylsilylstilbene 
• 1257321-09-7 3,4'-dimethoxy-4,5-ethylenedioxy-3'-O-t-butyldimethylsilylstilbene 
• 1257321-24-6 3'-hydroxy-4,5-ethylenedioxy-3,4'-dimethoxy-(E)-stilbene 
• 1257321-23-5 3'-hydroxy-4,5-ethylenedioxy-3,4'-dimethoxy-(Z)-stilbene 

Relevant articles and documents

CO2-Catalyzed oxidation of benzylic and allylic alcohols with DMSO

CO2-catalyzed transition-metal-free oxidation of alcohols has been achieved. Earlier, several methodologies have been explored for alcohol oxidations based on transition-metal catalysts. However, owing to the cheaper price, easy separation and nontoxicity, transition-metal-free systems are in high demand to the pharmaceutical industries. For this reason, various primary and secondary alcohols have been selectively oxidized to the corresponding carbonyl compounds using CO2 as a catalyst in the presence of different functional groups such as nitrile, nitro, aldehyde, ester, halogen, ether, and so on. At the end, transition-metal-free syntheses of pharmaceuticals have also been achieved. Finally, the role of CO2 has been investigated in detail, and the mechanism is proposed on the basis of experiments and DFT calculations.

Cis -restricted 3-aminopyrazole analogues of combretastatins: Synthesis from plant polyalkoxybenzenes and biological evaluation in the cytotoxicity and phenotypic sea urchin embryo assays

We have synthesized a series of novel cis-restricted 4,5-polyalkoxydiaryl- 3-aminopyrazole analogues of combretastatins via short synthetic sequences using building blocks isolated from dill and parsley seed extracts. The resulting compounds were tested in vivo in the phenotypic sea urchin embryo assay to reveal their antimitotic and antitubulin effects. The most potent aminopyrazole, 14a, altered embryonic cell division at 10 nM concentration, exhibiting microtubule-destabilizing properties. Compounds 12a and 14a displayed pronounced cytotoxicity in the NCI60 anticancer drug screen, with the ability to inhibit growth of multi-drug-resistant cancer cells.

Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases

The present invention provide a compound of formula I or II: or a pharmaceutically acceptable derivative thereof, wherein R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli; and Src-family kinases, especially Src and Lck kinases. These compounds are also inhibitors of GSK3 and CDK2 kinases. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.