759-02-4

Usage

Uses

Used in Flavoring and Fragrance Industry:
2,4-Pentanedione, 3-fluoro(6CI,8CI,9CI) is used as a flavoring and fragrance ingredient due to its ability to impart specific scents and tastes to various products. The fluoro-substitution may enhance or alter the sensory profile of the compound, making it suitable for creating unique aromas and flavors.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2,4-Pentanedione, 3-fluoro(6CI,8CI,9CI) may be utilized as an intermediate in the synthesis of various pharmaceutical compounds. The fluoro-substituted ketone could be a key component in the development of new drugs, potentially offering improved pharmacokinetic or pharmacodynamic properties.
Used in Agrochemical Industry:
2,4-Pentanedione, 3-fluoro(6CI,8CI,9CI) could also find applications in the agrochemical industry, where it may serve as a building block for the synthesis of agrochemicals such as pesticides or herbicides. The fluoro-substituted ketone might contribute to the effectiveness or selectivity of these products.
Further Research and Analysis:
The specific chemical and physical properties of 2,4-Pentanedione, 3-fluoro(6CI,8CI,9CI), as well as its potential hazards and broader uses, would require additional research and analysis. This would involve understanding its reactivity, stability, and compatibility with other compounds, which could inform its suitability for various applications and industries.

Upstream product

• 430-51-3 1-fluoro-2-propanone 
• 108-24-7 acetic anhydride 
• 13257-81-3 4-trimethylsiloxy-3-penten-2-one 
• 123-54-6 acetylacetone 
• 1694-29-7 3-chloropentane-2,4-dione 

Downstream Products

• 144219-90-9 4-fluoro-3,5-dimethyl-1-phenyl-1H-pyrazole 
• 100818-58-4 ethyl 3,5-dimethyl-4-fluoropyrrole-2-carboxylate 
• 57160-76-6 4-fluoro-3,5-dimethyl-1H-pyrazole 

Relevant academic research and scientific papers

C-F Bond Activation of a Perfluorinated Ligand Leading to Nucleophilic Fluorination of an Organic Electrophile

We report a fluorine transfer reaction in which fluorine from a perfluorinated ligand undergoes C-F bond activation and transfers to an electrophile, resulting in the formation of a new fluorinated product and dimerization of the monodefluorinated complex. Treatment of [(η5,κ2C-C5Me4CH2C6F5CH2NC3H2NMe)-RhCl] with the organic electrophile, toluoyl chloride, resulted in the formation of a rhodium(III) metallocycle via C-F bond activation assisted defluorinative coupling. Fission of the C-F bond liberated nucleophilic fluoride, which converted acyl chloride to acyl fluoride. The overall reaction was monitored using a multivariate analysis approach in real time.

Recyclable Organocatalysts for a One-Pot Asymmetric Synthesis of 2-Fluorocyclohexanols Bearing Six Contiguous Stereocenters

A recyclable fluorous bifunctional Cinchona alkaloid/thiourea-catalyzed quadruple fluorination/Michael/Michael/aldol sequence has been developed for the one-pot synthesis of cyclohexanols bearing six contiguous stereocenters including a fluorinated tertiary carbon. By using readily available starting materials including β-keto esters, β-nitrostyrenes, and α,β-unsaturated aldehydes, fully functionalized cyclohexanols were synthesized in 52–80% yields with up to 99% ee and >20:1 dr. The fluorous catalyst could be easily recovered by fluorous solid-phase extraction in 94–97% yield and >98% purity. In addition to the high synthetic efficiency achieved through the pot economic reactions, other green techniques such as transition metal-free catalysis and catalyst recovery are also employed. (Figure presented.).

One-pot fluorination and Mannich reactions of 1,3-dicarbonyl compounds

Abstract One-pot fluorination of 1,3-dicarbonyl compounds with Selectfluor followed by the Mannich reaction with anilines and benzaldehydes is developed for the synthesis of α-fluoro and aminomethylated 1,3-dicarbonyl compounds.

AZAINDAZOLES

Herein are disclosed azaindazoles of formula (I), (I), where the various groups are defined herein, and which are useful for treating cancer.

One-pot fluorination followed by Michael addition or Robinson annulation for preparation of α-fluorinated carbonyl compounds

Fluorination followed by the Michael addition or Robinson annulation of 1,3-dicarbonyl compounds is introduced for the synthesis of acyclic and cyclic α-fluoro-β-ketoesters and α-fluoro-1,3-diketones. The decarboxylation step can also be added to the reac

Continuous gas/liquid-liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination

4-Fluoropyrazole systems may be prepared by a single, sequential telescoped two-step continuous gas/liquid-liquid/liquid flow process from diketone, fluorine gas and hydrazine starting materials.

Microwave-mediated pyrazole fluorinations using selectfluor

Microwave-mediated electrophilic fluorinations and a new single-pot condensation en route to ring-fluorinated pyrazoles were examined: chemical equation represented The monofluorination by these methods was successful for a variety of pyrazoles, with yields ranging from 13% to 75%. While electrophilic aromatic fluorination of 3-CF3 pyrazoles proved largely ineffective, development ofa single-pot process overcame this limitation. The microwave-mediated reaction is regioselective; ring fluorination of the heterocycle occurs preferentially over phenyl and alkyl substituents. Alkyl side chain fluorination, when desired, can be modulated by reactant ratios. The single-pot method, which involves acid catalysis by H-TEDA, produces 4-fluoropyrazoles products.

Reactions of trifluoroamine oxide: A new method for selective fluorination of 1,3-diketones and β-ketoesters

Fluorination of 1,3-diketones and β-ketoesters with trifluoroamine oxide in the presence of tetrabutylammonium hydroxide (TBAH) provides a one step route to mono- and difluoro-products selectively fluorinated at the α-position in good yields.

Preparation of fluorinated dicarbonyls

PCT No. PCT/GB94/02547 Sec. 371 Date Feb. 21, 1997 Sec. 102(e) Date Feb. 21, 1997 PCT Filed Nov. 18, 1994 PCT Pub. No. WO95/14646 PCT Pub. Date Jun. 1, 1995A method for the fluorination of 1,3-diketones and 1,3-ketoesters is disclosed.

Direct fluorination of 1,3-dicarbonyl compounds

In acid media, 1,3-diketones and 1,3-keloesters can be fluorinated in high yield and often with high conversion mainly to the corresponding 2-fluoro- compounds. Diesters such as diethyl malonate do not react with fluorine under the same reaction conditions. The mechanism of these reactions has been investigated and while the identity of the electrophilic fluorinating species is uncertain, we believe that the essential features of the reaction pathway are understood. Copyright