75921-20-9

Upstream product

• 75921-19-6 Benzyl-5-O-tert-butyldimethylsilyl-2,3-O-isopropyliden-β-D-ribofuranosid 
• 67814-68-0 2,3-O-isopropylidene-D-ribofuranose 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 70266-87-4 6-hydroxymethyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol 

Downstream Products

• 91510-80-4 phenyl 5-O-(tert-butyldimethylsilyl)-2,3-O-isopropylidene-1-thio-α-D-ribofuranoside 
• 86475-58-3 ethyl 2-(5'-O-t-butyldimethylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-2-(phenylseleno)propionate 
• 112114-58-6 3,6-anhydro-7-benzenesulfonamido-1,7-dideoxy-4,5-O-isopropylidene-D-altro-hept-1-ynitol 
• 112114-63-3 (3aR,4R,20R,20aR,23aS,24R,29R,29aS)-25,26,27,28-tetradehydro-3a,4,5,6,7,17,18,19,20,20a,23a,24,29,29a-tetradecahydro-2,2,22,22-tetramethyl-6,18-bis(phenylsulfonyl)-4,29:20,24-diepoxy-8,11:13,16-diethenobis<1,3>dioxolo<4,5-j:4',5'-r><1,7,22>oxadiazacy... 
• 112114-59-7 7,7'->bis<3,6-anhydro-1,7-dideoxy-4,5-O-isopropylidene-D-altro-hept-1-ynitol> 
• 1040271-86-0 C₂₈H₂₉NO₇ 
• 1040272-24-9 4-(tert-Butyl-dimethyl-silanyloxymethyl)-6-chloro-2,2-dimethyl-5-phenylselanyl-tetrahydro-cyclopenta[1,3]dioxol-4-ol 
• 910138-81-7 C₃₁H₃₅NO₈S 
• 910138-85-1 C₂₈H₂₉NO₇ 
• 16754-86-2 4-(methylthio)-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine 
• 16754-80-6 4-chloro-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine 
• 115479-39-5 4-chloro-7-<5-O-<(1,1-dimethylethyl)dimethylsilyl>-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine 
• 120401-32-3 4-chloro-7-(α-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine 
• 69-33-0 tubercidin 

Relevant academic research and scientific papers

TRICYCLIC-NUCLEOSIDE COMPOUNDS FOR TREATING VIRAL INFECTIONS

Disclosed are tricyclic nucleoside compounds of formula (I), and methods thereof for treating viral infections mediated at least in part by a Flaviviridae family virus.

Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase

Several 7-deaza-6-benzylthioinosine analogues with varied substituents on aromatic ring were synthesized and evaluated against Toxoplasma gondii adenosine kinase (EC.2.7.1.20). Structure-activity relationships indicated that the nitrogen atom at the 7-position does not appear to be a critical structural requirement. Molecular modeling reveals that the 7-deazapurine motif provided flexibility to the 6-benzylthio group as a result of the absence of H-bonding between N7 and Thr140. This flexibility allowed better fitting of the 6-benzylthio group into the hydrophobic pocket of the enzyme at the 6-position. In general, single substitutions at the para or meta position enhanced binding. On the other hand, single substitutions at the ortho position led to the loss of binding affinity. The most potent compounds, 7-deaza-p-cyano-6- benzylthioinosine (IC50 = 5.3 μM) and 7-deaza-p-methoxy-6- benzylthioinosine (IC50 = 4.6 μM), were evaluated in cell culture to delineate their selective toxicity.