75928-89-1Relevant academic research and scientific papers
Urea as an ammonia surrogate in the hantzsch’s synthesis of polyhydro-quinolines / 1,4-dihydropyridines under green reaction conditions
Anna, Venkateswara Rao,Dhananjaya, G.,Mahesh Kumar, P.,Narayana Murthy, V.,Pal, Manojit,Pulla Reddy, S.,Raghunadh, Akula
supporting information, p. 226 - 232 (2021/03/19)
Synthesis of polyhydroquinolines via Hantzsch’s multicomponent reaction (MCR) involves the use of a hygroscopic and moderately toxic ammonium salt as one of the key reactants. In our effort, we have found urea as an effective ammonia surrogate when the MC
Reinvestigation of the Reaction of Ethyl 4,4,4-Trifluoroacetoacetate with Aldehydes and Ammonia
Singh, Baldev,Lesher, George Y.
, p. 1109 - 1110 (2007/10/02)
Reaction of ethyl 4,4,4-trifluoroacetoacetate with aromatic aldehydes and ammonia gives diethyl 4-aryl-2,6-dihydroxy-2,6-bis(trifluoromethyl)-3,5-piperidinedicarboxylates (4) instead of diethyl 4-aryl-1,4-dihydro-2,6-bis(trifluoromethyl)-3,5-pyridinedicar
