759417-05-5Relevant academic research and scientific papers
3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. 4. Side Chain Ester Derivatives of Mevinolin
Hoffman, W. F.,Alberts, A. W.,Anderson, P. S.,Chen, J. S.,Smith, R. L.,Willard, A. K.
, p. 849 - 852 (1986)
Modification of the 2(S)-methylbutyryl moiety of mevinolin led to a series of side chain ester derivatives.A systematic exploration of the structure-activity relationships showed that the introduction of an additional aliphatic group on the carbon α to the carbonyl group increased potency.This obsrevation led to the synthesis of compound 16, which has about 2.5 times the intrinsic inhibitory activity of mevinolin.
