759443-28-2

Upstream product

• 110-85-0 piperazine 
• 2367-76-2 2,4,6-trifluorobromobenzene 

Downstream Products

• 1355156-03-4 2-{3-(4-chlorobenzoyl)-4-[(4-(2,4,6-trifluorophenyl)piperazin-1-yl)methyl]thiophen-2-yl}-isoindole-1,3-dione 
• 1027492-84-7 {2-amino-4-[(4-(2,4,6-trifluorophenyl)piperazin-1-yl)methyl]thiophen-3-yl}(4-chlorophenyl)methanone 
• 1355156-54-5 2-{5-bromo-3-(4-chlorobenzoyl)-4-[(4-(2,4,6-trifluorophenyl)piperazin-1-yl)methyl]thiophen-2-yl}-isoindole-1,3-dione 

Relevant academic research and scientific papers

Potent, selective, and orally active adenosine A2A receptor antagonists: Arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines

Antagonism of the adenosine A2A receptor offers great promise in the treatment of Parkinson's disease. Employing the known pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine A2A antagonist SCH 58261 as a starting point, we identified the potent and selective (vs. A1) antagonist 11 h, orally active in the rat haloperidol-induced catalepsy model. We further optimized this lead to the methoxyethoxyethyl ether 12a (SCH 420814), which shows broad selectivity, good pharmacokinetic properties, and excellent in vivo activity.