759458-82-7Relevant academic research and scientific papers
Catalytic asymmetric conjugate addition/oxidative dearomatization towards multifunctional spirocyclic compounds
Rudolph, Alena,Bos, Pieter H.,Meetsma, Auke,Minnaard, Adriaan J.,Feringa, Ben L.
, p. 5834 - 5838 (2011)
Naphthol compounds bearing a pendant α,β-unsaturated ester undergo a copper(I)-catalyzed asymmetric conjugate addition/copper(II)-mediated intramolecular oxidative coupling to afford benzofused spirocyclic cyclohexenones (see scheme). This one-pot strategy results in two new carbon-carbon bonds and three contiguous stereocenters. The products contain a high degree of functionality and molecular complexity.
