75959-47-6Relevant academic research and scientific papers
Powerful Claisen condensation and Claisen-aldol tandem reaction of α,α-dialkylated esters promoted by ZrCl4-iPr2NEt
Tanabe,Hamasaki,Funakoshi
, p. 1674 - 1675 (2007/10/03)
Powerful Claisen ester condensations of α,α-dialkylated esters mediated by ZrCl4-iPr2NEt were performed to give the corresponding thermodynamically unfavorable α,α-dialkylated β-ketoesters, and Claisen-aldol tandem reactions between an intermediary Zr-enolate of a α,α-dialkylated β-ketoester and aldehydes also proceeded.
Ethyl 3-Aryl-3-hydroxy-2,2-dimethylpropionates and 6-Aryl-3,3,5,5-tetramethyltetrahydropyran-2,4-diones
Unterhalt, Bernard,Weyrich, Klaus
, p. 795 - 799 (2007/10/02)
The chloroketones 1 react with equimolar amounts of a 10percent solution of sodium hydroxide in acetone to give the hydroxyketones 2.They were to be transformed into the substituted ethyl propionates 5 which are similar to clofibrate.As this synthesis fai
