7596-80-7

Usage

Uses

Used in Organic Synthesis:
1,2-BIS(METHANESULFONAMIDO)BENZENE is used as a protecting group for alcohols and amines, ensuring that these functional groups remain intact during the course of a reaction. This application is crucial for the successful synthesis of complex organic molecules, as it prevents unwanted side reactions and allows for selective functionalization of specific sites within a molecule.
Used in Pharmaceutical Synthesis:
As a building block, 1,2-BIS(METHANESULFONAMIDO)BENZENE is utilized in the synthesis of various pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new drugs, potentially leading to the discovery of novel therapeutic agents with improved efficacy and safety profiles.
Used in Agrochemical Synthesis:
Similarly, in the agrochemical industry, 1,2-BIS(METHANESULFONAMIDO)BENZENE serves as a key building block for the synthesis of new agrochemicals. Its incorporation into the molecular structures of these compounds can enhance their pesticidal or herbicidal properties, contributing to more effective and environmentally friendly agricultural practices.
Safety Considerations:
While 1,2-BIS(METHANESULFONAMIDO)BENZENE is considered relatively safe when handled and used in a laboratory setting, it is essential to follow proper safety precautions to minimize exposure to 1,2-BIS(METHANESULFONAMIDO)BENZENE. This includes wearing appropriate personal protective equipment, working in well-ventilated areas, and adhering to established laboratory protocols to ensure the safety of both researchers and the environment.

InChI:InChI=1/C8H12N2O4S2/c1-15(11,12)9-7-5-3-4-6-8(7)10-16(2,13)14/h3-6,9-10H,1-2H3

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 135299-16-0 N-2'-hydroxyethyl-1,2-bis(mesylamide)-benzene 
• 135299-17-1 N,N'-bis(2'-hydroxyethyl)-1,2-bis(mesylamide)-benzene 

Relevant academic research and scientific papers

High-Spin Cobalt(II) Complex with Record-Breaking Anisotropy of the Magnetic Susceptibility According to Paramagnetic NMR Spectroscopy Data

Abstract: The tetrahedral cobalt(II) complex [CoL2](HNEt3)2 (I), where L is 1,2-bis(methanesulfonamido)benzene, exhibiting the properties of a single-molecule magnet is synthesized and characterized. The electronic structu

A Versatile Synthesis of Vinyl-Substituted Heterocycles via Regio- And Enantioselective Pd-Catalyzed Tandem Allylic Substitution

We herein report a versatile, regio- and enantioselective palladium-catalyzed tandem allylic substitution powered by a chiral bisphosphorus ligand WingPhos with the palladium loading as low as 0.1 mol %, forming a series of chiral vinyl-substituted heterocycles, including tetrahydroquinoxalines, piperazines, dihydro-2H-benzo[b][1,4]-oxazines, and morpholines, in exellent ee's and yields. The protocol features readily available starting materials, mild reaction conditions, and a broad substrate scope. Mechanistic investigation supports a tandem allylic substitution process.

Pd(II)-Catalyzed Aerobic Intermolecular 1,2-Diamination of Conjugated Dienes: A Regio- and Chemoselective [4 + 2] Annulation for the Synthesis of Tetrahydroquinoxalines

A Pd(II)-catalyzed aerobic intermolecular 1,2-diamination of conjugated dienes was developed for the regio- and chemoselective preparation of a variety of functionalized tetrahydroquinoxalines, using simple sulfonyl protected o-phenylendiamines as a nitrogen source. This methodology provides a direct and efficient synthesis of tetrahydroquinoxalines. O2 was used as the stoichiometric oxidant, and reaction conditions were applied to a series of o-phenylendiamines and conjugated dienes. 35 examples are described, and good yields and selectivities are obtained for the majority of the products.

Synthesis of spirocyclic aminosilanes with electron withdrawing substituents at nitrogen

The first synthesis of spirocyclic tetrasulfonamidosilanes is described. According to the X-Ray structure analysis of the most stable tetratosylamidosilane obtained the Silicon is bonded to four Nitrogen atoms in a spirocycle and surrounded by four Oxygen