7597-97-9

Usage

Uses

Used in Food Industry:
2-tert-butyl-4-isopropylphenol is used as a preservative in the food industry to extend the shelf life of products by preventing oxidation and spoilage, ensuring freshness and quality.
Used in Cosmetics Industry:
In the cosmetics industry, 2-tert-butyl-4-isopropylphenol is used as an antioxidant to protect products from degradation, maintaining their efficacy and quality over time.
Used in Pharmaceutical Industry:
2-tert-butyl-4-isopropylphenol is utilized as a stabilizing agent in pharmaceuticals to prevent the oxidation of sensitive ingredients, thereby preserving the potency and safety of medications.
Used in Plastics and Rubber Industry:
2-tert-butyl-4-isopropylphenol is employed as an antioxidant in the plastics and rubber industry to prevent the deterioration of materials, enhancing their durability and performance.
Used in Petroleum Industry:
In the petroleum industry, 2-tert-butyl-4-isopropylphenol is used to inhibit the oxidation of fuels and lubricants, reducing the formation of harmful byproducts and extending the useful life of these products.

InChI:InChI=1/C13H20O/c1-9(2)10-6-7-12(14)11(8-10)13(3,4)5/h6-9,14H,1-5H3

Upstream product

• 99-89-8 4-Isopropylphenol 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 1609538-07-9 C₁₃H₁₈O₂ 

Relevant academic research and scientific papers

Controlling the catalytic aerobic oxidation of phenols

The oxidation of phenols is the subject of extensive investigation, but there are few catalytic aerobic examples that are chemo- and regioselective. Here we describe conditions for the ortho-oxygenation or oxidative coupling of phenols under copper (Cu)-catalyzed aerobic conditions that give rise to ortho-quinones, biphenols or benzoxepines. We demonstrate that each product class can be accessed selectively by the appropriate choice of Cu(I) salt, amine ligand, desiccant and reaction temperature. In addition, we evaluate the effects of substituents on the phenol and demonstrate their influence on selectivity between ortho-oxygenation and oxidative coupling pathways. These results create an important precedent of catalyst control in the catalytic aerobic oxidation of phenols and set the stage for future development of catalytic systems and mechanistic investigations.

Mechanistic basis for high stereoselectivity and broad substrate scope in the (salen)Co(III)-catalyzed hydrolytic kinetic resolution

In the (salen)Co(III)-catalyzed hydrolytic kinetic resolution (HKR) of terminal epoxides, the rate- and stereoselectivity-determining epoxide ring-opening step occurs by a cooperative bimetallic mechanism with one Co(III) complex acting as a Lewis acid and another serving to deliver the hydroxide nucleophile. In this paper, we analyze the basis for the extraordinarily high stereoselectivity and broad substrate scope observed in the HKR. We demonstrate that the stereochemistry of each of the two (salen)Co(III) complexes in the rate-determining transition structure is important for productive catalysis: a measurable rate of hydrolysis occurs only if the absolute stereochemistry of each of these (salen)Co(III) complexes is the same. Experimental and computational studies provide strong evidence that stereochemical communication in the HKR is mediated by the stepped conformation of the salen ligand, and not the shape of the chiral diamine backbone of the ligand. A detailed computational analysis reveals that the epoxide binds the Lewis acidic Co(III) complex in a well-defined geometry imposed by stereoelectronic rather than steric effects. This insight serves as the basis of a complete stereochemical and transition structure model that sheds light on the reasons for the broad substrate generality of the HKR.