75970-47-7

Usage

Uses

Used in Pharmaceutical Industry:
(1H-Benzimidazol-2-yl)-piperidin-4-yl-amine 2HBr serves as a pharmaceutical intermediate, playing a crucial role in the synthesis of potential drugs. Its capacity to bind with particular receptors in the body makes it instrumental in the creation of new medications aimed at treating neurological disorders, psychiatric illnesses, and pain management.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (1H-Benzimidazol-2-yl)-piperidin-4-yl-amine 2HBr is utilized as a valuable research tool. Its unique structure and properties contribute to the advancement of knowledge and the development of innovative therapeutic agents, enhancing the discovery and design of novel drugs with improved efficacy and safety profiles.

InChI:InChI=1/C12H16N4.2BrH/c1-2-4-11-10(3-1)15-12(16-11)14-9-5-7-13-8-6-9;;/h1-4,9,13H,5-8H2,(H2,14,15,16);2*1H

Upstream product

• 73734-07-3 (1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine 
• 73733-81-0 ethyl 4-{[(2-aminophenyl)aminothioxomethyl]amino}-1-piperidinecarboxylate 
• 73733-70-7 ethyl 4-isothiocyanato-1-piperidinecarboxylate 
• 58859-46-4 ethyl 4-aminopiperidine-1-carboxylate 

Downstream Products

• 73734-32-4 N-[1-(2-phenylethyl)-4-piperidinyl]-1-(phenylmethyl)-1H-benzimidazol-2-amine 
• 73736-18-2 N-[1-(2-phenylethyl)-4-piperidinyl]-1-(2-pyridinylmethyl)-1H-benzimidazol-2-amine 
• 73736-15-9 (1-Phenethyl-1H-benzoimidazol-2-yl)-(1-phenethyl-piperidin-4-yl)-amine 
• 73734-87-9 (1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-amine 
• 73735-53-2 (1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(4-chloro-phenyl)-ethyl]-piperidin-4-yl}-amine 
• 73734-44-8 [1-(2-Fluoro-benzyl)-1H-benzoimidazol-2-yl]-(1-phenethyl-piperidin-4-yl)-amine 
• 75971-18-5 1-[1-(4-fluorophenyl)ethyl]-N-[1-(2-phenylethyl)-4-piperidinyl]-1H-benzimidazol-2-amine 
• 73735-48-5 N-{1-[3-(methoxyphenyl)ethyl]-4-piperidinyl}-1-(phenylmethyl)-1H-benzimidazol-2-amine 
• 73735-49-6 (1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(4-ethoxy-phenyl)-ethyl]-piperidin-4-yl}-amine 
• 73736-17-1 (1-Phenethyl-piperidin-4-yl)-[1-(2-phenyl-propyl)-1H-benzoimidazol-2-yl]-amine 
• 73735-45-2 (1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(3,4-dimethoxy-phenyl)-ethyl]-piperidin-4-yl}-amine 
• 73736-20-6 {1-[Bis-(4-fluoro-phenyl)-methyl]-1H-benzoimidazol-2-yl}-(1-phenethyl-piperidin-4-yl)-amine 
• 73734-88-0 (1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(3-trifluoromethyl-phenyl)-ethyl]-piperidin-4-yl}-amine 
• 73735-54-3 (1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-piperidin-4-yl}-amine 

Relevant academic research and scientific papers

Synthesis and anti-Plasmodium activity of benzimidazole analogues structurally related to astemizole

A series of compounds structurally related to astemizole were designed and synthesized with the goal of determining their anti-Plasmodium activity. Several modifications of the astemizole structure, namely the removal of the 4-fluorobenzyl and/ or 4-methoxyphenethyl moieties, substitution of the benzene ring of the benzimidazole scaffold, replacement of the fluorine atom in the 4-fluorobenzyl group, and variation of the 4-aminopiperidine moiety, were explored. In vitro evaluation of the anti-Plasmodium activity of these compounds using the ItG strain showed that astemizole and some of its structurally similar derivatives have IC50 values in the nanomolar range and exhibit toxicity towards the parasite over Chinese ovarian hamster (CHO) cells with a selectivity as high as 200. The presence of a secondary cyclic amine at position 2 and substitution with chlorine at positions 4 and 5 in the benzimidazole moiety are two modifications that resulted in potent and selective antimalarials based on astemizole.