75970-76-2

Basic information

• Product Name: 1H-Benzimidazol-2-amine, 1-(phenylmethyl)-N-4-piperidinyl-
• CAS NO: 75970-76-2
• Molecular Formula: C19H22N4
• Molecular Weight: 306.41
• Mol File: 75970-76-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazol-2-amine, 1-(phenylmethyl)-N-4-piperidinyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazol-2-amine, 1-(phenylmethyl)-N-4-piperidinyl-(75970-76-2)
• EPA Substance Registry System: 1H-Benzimidazol-2-amine, 1-(phenylmethyl)-N-4-piperidinyl-(75970-76-2)

Safety Data

• Hazardous Substances Data: 75970-76-2(Hazardous Substances Data)

Upstream product

• 73733-81-0 ethyl 4-{[(2-aminophenyl)aminothioxomethyl]amino}-1-piperidinecarboxylate 
• 83898-30-0 ethyl 4-((1-benzyl-1H-benzo[d]imidazol-2-yl)amino)piperidine-1-carboxylate 
• 73734-07-3 (1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine 
• 58859-46-4 ethyl 4-aminopiperidine-1-carboxylate 

Downstream Products

• 73735-96-3 N-(1-cyclohexyl-4-piperidinyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine 
• 73735-61-2 (1-benzyl-1H-benzimidazol-2-yl)-(1-(2-(4-methoxyphenyl)ethyl)-piperidin-4-yl)amine 
• 73734-92-6 (1-Benzyl-1H-benzoimidazol-2-yl)-{1-[4,4-bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-amine 
• 98244-88-3 4-[4-(1-Benzyl-1H-benzoimidazol-2-ylamino)-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one 
• 98245-11-5 (1-Benzyl-1H-benzoimidazol-2-yl)-{1-[2-(2-methoxy-phenyl)-ethyl]-piperidin-4-yl}-amine 
• 98244-87-2 (1-Benzyl-1H-benzoimidazol-2-yl)-[1-(3-phenoxy-propyl)-piperidin-4-yl]-amine 
• 75970-77-3 (1-Benzyl-1H-benzoimidazol-2-yl)-[1-(2-phenoxy-ethyl)-piperidin-4-yl]-amine 
• 98245-10-4 (1-Benzyl-1H-benzoimidazol-2-yl)-[1-(2-m-tolyl-ethyl)-piperidin-4-yl]-amine 
• 98244-84-9 (1-Benzyl-1H-benzoimidazol-2-yl)-[1-(3-phenyl-propyl)-piperidin-4-yl]-amine 
• 98244-85-0 (1-Benzyl-1H-benzoimidazol-2-yl)-[1-((E)-3-phenyl-allyl)-piperidin-4-yl]-amine 
• 73734-82-4 (1-Benzyl-1H-benzoimidazol-2-yl)-(1-benzyl-piperidin-4-yl)-amine 
• 98244-80-5 (1-Benzyl-1H-benzoimidazol-2-yl)-(1-butyl-piperidin-4-yl)-amine 
• 98244-81-6 (1-Allyl-piperidin-4-yl)-(1-benzyl-1H-benzoimidazol-2-yl)-amine 
• 75971-14-1 N-(1-methyl-4-piperidinyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine 

Relevant articles and documents

Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction

Disruption of EZH2-embryonic ectoderm development (EED) protein-protein interaction (PPI) is a new promising cancer therapeutic strategy. We have previously reported the discovery of astemizole, a small-molecule inhibitor targeting the EZH2-EED PPI. Herein, we report the cocrystal structure of EED in complex with astemizole at 2.15 ?. The structure elucidates the detailed binding mode of astemizole to EED and provides a structure-guided design for the discovery of a novel EZH2-EED interaction inhibitor, DC-PRC2in-01, with an affinityKdof 4.56 μM. DC-PRC2in-01 destabilizes the PRC2 complex, thereby leading to the degradation of PRC2 core proteins and the decrease of global H3K27me3 levels in cancer cells. The proliferation of PRC2-driven lymphomas cells is effectively inhibited, and the cell cycle is arrested in the G0/G1 phase. Together, these data demonstrate that DC-PRC2in-01 could be an effective chemical probe for investigating the PRC2-related physiology and pathology and providing a promising chemical scaffold for further development.