75994-19-3

Upstream product

• 76012-87-8 4-[(4-Methanesulfonyl-phenyl)-hydrazono]-6,8-dimethyl-1-oxo-isochroman-7-carboxylic acid ethyl ester 
• 94568-86-2 3-(4-Methanesulfonyl-phenyl)-5,7-dimethyl-4-oxo-3,4-dihydro-phthalazine-1,6-dicarboxylic acid diethyl ester 
• 56611-61-1 6-ethoxycarbonyl-5,7-dimethyl-3-hydroxy-3-methylphthalide 
• 17852-67-4 4-(methylsulfonyl)phenylhydrazine hydrochloride 
• 56611-71-3 7-ethoxycarbonyl-6,8-dimethyl-isochroman-1,4-dione 
• 877-66-7 4-(methylsulfonyl)phenylhydrazine 

Relevant academic research and scientific papers

Synthesis and inhibitory effects on platelet aggregation of phthalazinone derivatives

7-Ethoxycarbonyl-4-hydroxymethyl-6,8-dimethyl-2-phenyl-1(2H)-phthalazinon e 7a and its derivatives having various substituents on the benzene ring at the 2 position were prepared and their inhibitory activities on platelet aggregation were assayed. The parent compound and those having an ortho substituent such as fluorine, chlorine atom or a methyl group showed the most potent inhibitory activity. Their inhibitory mechanism on platelet aggregation was assumed to be inhibition of cyclooxygenase, resulting in prevention of prostaglandin synthesis.