75997-20-5Relevant articles and documents
A robust first-pass protocol for the heck-mizoroki reaction
Murray, Paul M.,Bower, John F,Cox, David K,Galbraith, Ewan K,Parker, Jeremy S,Sweeney, Joseph B.
, p. 397 - 405 (2013/04/24)
The Heck-Mizoroki (HM) reaction is one of the most widely used C-C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions frequently require significant optimization before efficient transformations can be obtained. We describe here the results of a study that aimed to establish a generic experimental protocol for HM reactions which enables acceptable yields from first-pass experiments. The methodology utilizes readily available stable catalysts and can be applied to a broad range of coupling partners.
