75998-21-9

Usage

Uricosuric agent

A drug that promotes the excretion of uric acid This property makes it useful for treating conditions like chronic gout by increasing the amount of uric acid expelled through urine.

Inhibition of uric acid reabsorption in kidneys

Benzbromarone works by inhibiting the reabsorption of uric acid in the kidneys, which helps to reduce uric acid levels in the blood.

Anti-inflammatory properties

Benzbromarone has the ability to reduce inflammation, which is beneficial in treating the pain and swelling associated with gout, a form of arthritis.

Anti-oxidant properties

The compound also has anti-oxidant properties, which can help protect cells from damage caused by free radicals and oxidative stress.

Treatment for chronic gout

Benzbromarone is used specifically for the treatment of chronic gout, a condition caused by the buildup of uric acid crystals in the joints.

Liver toxicity

One of the side effects of benzbromarone is its potential to cause liver toxicity, which limits its use as a first-line treatment for gout.

Not commonly used as a first-line treatment for gout

Due to the risk of liver toxicity, benzbromarone is generally not the first choice for treating gout and may be prescribed when other treatments have not been effective.

Upstream product

• 615-15-6 2-Methyl-1H-benzimidazole 
• 85-44-9 phthalic anhydride 

Relevant academic research and scientific papers

BENZAZOL COMPOUND AND PIGMENT COMPOSITION COMPRISING THE SAME

PROBLEM TO BE SOLVED: To provide a compound that can be atomized and highly concentrated without aggregation, settling, or viscosity increase. SOLUTION: The invention provides a compound represented by the specified formula (1), where one of R1 to R8 is of the specified formula (2) (R10 is H or alkyl; each of R11 and R12 is alkyl or the like; Y is SO2 or -CO; and Z is alkylene or the like), and the others are H, alkyl, or the like; and X is O or S. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

BENZOAZOLE COMPOUND OR SALT THEREOF, AND PIGMENT COMPOSITION CONTAINING THE SAME

PROBLEM TO BE SOLVED: To provide a composition stable as a colorant of e.g., a resist for color filters, where a pigment composition containing an organic pigment is reduced in particle size and increased in concentration without causing aggregation, sedimentation, or a viscosity increase with time. SOLUTION: The present invention provides a benzoazole compound having a structure represented by a formula (1) or a salt thereof (where, R1-R8 are ahydrogen atom, a C1-4 alkyl group, a C1-4 alkoxy group, a halogen atom, a -CO2M group or a -SO3M group. M is a hydrogen atom, an alkali metal atom, an alkaline earth metal atom or a -NZ1Z2Z3Z4 group. Z1-Z4 are a hydrogen atom, a C1-4 alkyl group or the like. X is an oxygen atom or a sulfur atom or the like). SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

β-Diceto enamines heterocycliques: 1. Indanediones-1,3 substituees en 2 par un heterocycle azote

The condensation of methylated N-heterocycles and especially monomethyl- and polymethylpyridines on phthalic anhydrides leads to 2-aryl-1,3-indanediones.The 3-alkylidenylphthalides formed in an intermediary state have been isolated.The influence of solvents and temperature on the velocity and yield of formation of 2-(2- and 4-pyridyl)-1,3-indandiones has been studied.The ir and nmr spectra confirm that these compounds exist under a β-diketoenamine form resonating with a betaine form.