76-96-0

Basic information

• Product Name: 1,1',1''-phosphorothioyltris(2-methylaziridine)
• Synonyms: 1,1',1''-phosphorothioyltris(2-methylaziridine);Methiotepa;ENT 161A;tris(2-methylaziridin-1-yl)-sulfanylidene-$l^{5}-phosphane;tris(2-methylethylenimin-1-yl)-thioxo-phosphorane;Tris(2-methyl-1-aziridinyl)phosphine sulfide;NSC 56843;NSC 54055
• CAS NO: 76-96-0
• Molecular Formula: C9H18N3PS
• Molecular Weight: 231.298081
• EINECS: 200-995-3
• Product Categories: Pharmaceutical Raw Materials
• Mol File: 76-96-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 294.4°Cat760mmHg
• Flash Point: 131.8°C
• Appearance: /
• Density: 1.3g/cm³
• PKA: 3.80±0.40(Predicted)
• CAS DataBase Reference: 1,1',1''-phosphorothioyltris(2-methylaziridine)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1',1''-phosphorothioyltris(2-methylaziridine)(76-96-0)
• EPA Substance Registry System: 1,1',1''-phosphorothioyltris(2-methylaziridine)(76-96-0)

Safety Data

• Hazardous Substances Data: 76-96-0(Hazardous Substances Data)

Usage

Uses

Methiotepa is a trifunctional aziridine chemosterilant.

Upstream product

• 75-55-8 2-Methylaziridine 

Relevant articles and documents

In the search for new anticancer drugs. 26. A comparison of anticancer activities of several TEPA, Thio-TEPA, Seleno-TEPA, and azetidine analogs, including congeners containing an aminoxyl moiety

A series of TEPA, Thio-TEPA, Seleno-TEPA, and azetidine analogs, including congeners containing an aminoxyl moiety, were synthesized and evaluated in vivo for anticancer activity against the murine lymphocytic leukemia P388. All aziridine derivatives were found to be active with an increase in life span ranging from 42% to 272%, and all azetidine analogs were rated as inactive with one marginal exception. An attempt was made to rationalize the results on the basis of the lipophilic properties of the compounds. The most active compound (8) possessed the most balanced lipophilic properties, corresponding to a log P value near zero.