760-41-8Relevant academic research and scientific papers
NOVEL PRECURSORS
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Page/Page column 14-15, (2009/05/30)
The present invention relates to a Compound of the formula (I), wherein X represents CN, COOR, wherein R represents hydrogen or a carboxyl protecting group, CONR'2, wherein R' represents hydrogen or a carboxyl protecting group, or nitro; R1, R2, R3, R4, R5 independently of each other represent hydrogen, C1-C6 alkyl, halogen, trifluoromethyl, cyano, nitro, substituted aryl or substituted heteroaryl group; Y represents hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, C7-C13 alkaryl, trifluoromethyl, cyano, nitro, substituted aryl or substituted heteroaryl group; and wherein the stereochemically unspecified double bonds in the above formula (I) represent either the E,E; E,Z; Z,E or Z,Z configuration.
Reactions of Trifluoroacetyl Isocyanate
Kiemstedt, Wolfgang,Sundermeyer, Wolfgang
, p. 919 - 925 (2007/10/02)
Trifluoroacetyl isocyanate (1) can be obtained from trimethylsilyl isocyanate and trifluoroacetyl chloride. 1 reacts with trifluoroacetamide forming N,N'-bis(trifluoroacetyl)urea (2), which can also be obtained from trifluoroacetyl chloride and urea or N,N'-bis(trimethylsilyl)urea, respectively. 1 reacts with ammonia or various amines forming the trifluoroacetylsubstituted ureas 3 - 6, and hydrazine 7.From 1 and trifluoroacetic acid hexafluorodiacetamide (8) could be obtained. 1 reacts with tert-butylalcohol forming tert-butyl (trifluoroacetyl)carbamate (9).From 1 and N,N-dimethylformamide N,N-dimethyl-N'-(trifluoroacetyl)formamidine (10) could be obtained as well as N-(trifluoroacetyl)pyrrole-2-carboxamide (11) from pyrrole.
