870066-15-2

Basic information

• Product Name: 2-TRIFLUOROMETHYL-3-CYANOPYRIDINE
• Synonyms: 2-TRIFLUOROMETHYL-3-CYANOPYRIDINE;2-(Trifluoromethyl)pyridine-3-carBonitrile;2-(Trifluoromethyl)-3-cyanopyridine, 2-Trifluoromethylnicotinonitrile;3-Cyano-2-(trifluoromethyl)pyridine
• CAS NO: 870066-15-2
• Molecular Formula: C7H3F3N2
• Molecular Weight: 172.1073296
• Product Categories: Pyridines;Heterocyclic Compounds
• Mol File: 870066-15-2.mol

Chemical Properties

• Boiling Point: 208.3oC at 760 mmHg
• Flash Point: >110°C
• Appearance: /
• Density: 1.344
• Vapor Pressure: 0.215mmHg at 25°C
• Refractive Index: 1.4641
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-TRIFLUOROMETHYL-3-CYANOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-TRIFLUOROMETHYL-3-CYANOPYRIDINE(870066-15-2)
• EPA Substance Registry System: 2-TRIFLUOROMETHYL-3-CYANOPYRIDINE(870066-15-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 870066-15-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Trifluoromethyl-3-cyanopyridine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to enhance the biological activity and pharmacokinetic properties of the final drug products.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Trifluoromethyl-3-cyanopyridine is utilized as a building block in the development of new agrochemicals, contributing to the improvement of crop protection and yield enhancement.
Used in Dye and Pigment Production:
2-Trifluoromethyl-3-cyanopyridine is employed as a precursor in the production of dyes and pigments, offering unique color properties and improved stability compared to traditional dyes and pigments.
Used in Organic Synthesis:
Due to its high reactivity, 2-Trifluoromethyl-3-cyanopyridine is used as a versatile intermediate in organic synthesis for the preparation of a wide range of organic compounds with diverse applications in various industries.

InChI:InChI=1/C7H3F3N2/c8-7(9,10)6-5(4-11)2-1-3-12-6/h1-3H

Upstream product

• 557-21-1 zinc(II) cyanide 
• 590371-58-7 3-bromo-2-(trifluoromethyl)pyridine 
• 959108-47-5 2-(trifluoromethyl)nicotinamide 
• 1146961-23-0 5-(dimethylamino)-2-(2,2,2-trifluoroacetyl)penta-2,4-dienenitrile 

Downstream Products

• 923288-82-8 3-cyano-2-(trifluoromethyl)pyridine 1-oxide 
• 760-41-8 N-(Trifluoracetyl)harnstoff 
• 1056162-06-1 (2-(trifluoromethyl)pyridin-3-yl)methanamine 

Relevant articles and documents

COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors together with a second compound useful in the treatment of a neurodegenerative disorder and their combined use as a medicament, in particular for the treatment of neurodegenerative and/or cognitive disorders.

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors together with a second compound which compound is useful in the treatment of a psychiatric disorder and their combined use as a medicament, in particular for the treatment of psychiatric and/or cognitive disorders.

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

4,6-DIAMINONICOTINAMIDE COMPOUND

[Problem] The present invention provides a 4,6-diaminonicotinamide compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for treating diseases caused by undesirable and/or abnormal cytokine signal transduction. [Means for Solution] The present inventors have extensively studied compounds having a JAK3 inhibitory action, and as a result, they have found that a 4,6-diaminonicotinamide compound which is the compound of the present invention has an excellent JAK3 inhibitory action and is useful as an agent for preventing or treating diseases caused by undesirable and/or abnormal cytokine signal transduction, thereby completing the present invention.

NOVEL PRECURSORS

The present invention relates to a Compound of the formula (I), wherein X represents CN, COOR, wherein R represents hydrogen or a carboxyl protecting group, CONR'2, wherein R' represents hydrogen or a carboxyl protecting group, or nitro; R1, R2, R3, R4, R5 independently of each other represent hydrogen, C1-C6 alkyl, halogen, trifluoromethyl, cyano, nitro, substituted aryl or substituted heteroaryl group; Y represents hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, C7-C13 alkaryl, trifluoromethyl, cyano, nitro, substituted aryl or substituted heteroaryl group; and wherein the stereochemically unspecified double bonds in the above formula (I) represent either the E,E; E,Z; Z,E or Z,Z configuration.

Efficient synthesis of 2-(trifluoromethyl)nicotinic acid derivatives from simple fluorinated precursors

Novel routes to 2-trifluoromethyl-nicotinic acid derivatives have been developed Involving synthesis of the pyridine ring. These pyridyl compounds serve as key intermediates in the manufacture of the recently discovered COMT inhibitor, 3-(5-(3,4-dihydroxy