760-80-5

Usage

Uses

ETHYL 2-FLUOROACRYLATE is used as a monomer in the production of polymers and copolymers for various applications due to its unique properties, such as its ability to form stable and durable materials.
Used in Coatings Industry:
ETHYL 2-FLUOROACRYLATE is used as a component in the formulation of high-performance coatings, such as automotive and industrial coatings, because of its excellent adhesion, durability, and resistance to environmental factors.
Used in Adhesives Industry:
In the adhesives industry, ETHYL 2-FLUOROACRYLATE is used as a key ingredient in the development of strong and versatile adhesives that can bond various materials together, including metals, plastics, and glass.
Used in Medical Industry:
ETHYL 2-FLUOROACRYLATE is utilized in the medical field as a component in the synthesis of biocompatible materials for use in implants, prosthetics, and other medical devices, due to its compatibility with biological systems and resistance to degradation.
Used in Electronics Industry:
In the electronics industry, ETHYL 2-FLUOROACRYLATE is employed in the production of insulating materials and protective coatings for electronic components, ensuring their stability and longevity in various operating conditions.

Hazards

MFA is highly?flammable?and can be harmful if inhaled, in contact with?skin, or if swallowed. It is irritating to?eyes,?respiratory system, and skin.

InChI:InChI=1/C5H7FO2/c1-3-8-5(7)4(2)6/h2-3H2,1H3

Upstream product

• 50-00-0 formaldehyd 
• 459-72-3 ethyl 2-fluoroacetate 
• 1993-92-6 2-fluoro-3-hydroxypropionic acid ethyl ester 
• 2927-18-6 α,β-Dibrom-α-fluor-propionsaeure-aethylester 
• 1643-83-0 Ethyl 2-Fluoro-3-(4-toluenesulfonyloxy)propanoate 
• 64-17-5 ethanol 
• 16522-55-7 α-fluoroacryloyl chloride 
• 99953-32-9 2,3-Dichlor-2-fluorpropansaeureethylester 
• 111773-24-1 3-bromo-2,2-difluoropropionic acid ethyl ester 
• 2356-16-3 ethyl(diethylphosphono)(fluoro)acetate 
• 109-94-4 formic acid ethyl ester 
• 37996-11-5 2,2,3-tribromo-propionic acid ethyl ester 
• 108221-67-6 ethyl 2-bromo-2-fluoropropionate 
• 910803-66-6 ethyl α-(1,3-benzothiazol-2-ylsulfonyl)-α-fluoroacetate 

Downstream Products

• 42909-51-3 3-Chloro-2-fluoro-2-methylsulfanyl-propionic acid ethyl ester 
• 34148-77-1 Ethyl-α-fluoro-β-ethoxy-propionat 
• 34139-16-7 α-Fluoro-β-butylmercaptopropionsaeureethylester 
• 34139-20-3 Ethyl-α,α-difluoro-β-nitropropionat 
• 57975-70-9 3-Cyclohexylamino-2-fluoro-propionic acid ethyl ester 
• 57975-67-4 α-Fluoro-β-diethylaminopropionsaeure-ethylester 
• 34139-17-8 α-Fluoro-β-acetylmercaptopropionsaeureethylester 
• 42909-50-2 2-Chloro-2-fluoro-3-phenylsulfanyl-propionic acid ethyl ester 
• 42909-49-9 3-Chloro-2-fluoro-2-phenylsulfanyl-propionic acid ethyl ester 
• 1743-71-1 2-Fluor-4-ethoxycarbonyl-glutarsaeure-diethylester 
• 33666-37-4 (+/-)-1-Fluor-2,2-diphenylcyclopropancarbonsaeureaethylester 
• 1652-64-8 C-Acetamino-C-<2-fluor-2-aethoxycarbonyl-aethyl>-malonsaeure-diaethylester 
• 430-99-9 2-fluoroacrylic acid 
• 74893-46-2 2-fluoroprop-2-enoyloxysodium 

Relevant academic research and scientific papers

METHOD FOR PRODUCING 2-HALOGEN-ACRYLIC ACID ESTERS

The present invention relates to a process for preparing 2-haloacrylic esters from 2-hydroxymethyl- or 2-halomethyl- or 2-chlorosulfinyloxymethyl-2-halomalonic diesters. The invention further provides novel 2-halomethyl-2-halomalonic diesters or 2-chlorosulfinyloxymethyl-2-halomalonic diesters which can be used for preparation of the 2-haloacrylic esters.

PRODUCTION METHOD FOR ALPHA-FLUORO ACRYLIC ACID ESTERS

An object of the present invention is to provide a process for producing α-fluoroacrylic acid esters at a high starting material conversion and a high yield. The present invention provides, as a means to achieve the object, a process for producing a compound represented by formula (1): wherein R2 and R2 are the same or different and each represent alkyl, fluoroalkyl, aryl optionally substituted with at least one substituent, halogen, or hydrogen; and R3 represents alkyl, fluoroalkyl, or aryl optionally substituted with at least one substituent, the process comprising step A ofreacting a compound represented by formula (2): wherein the symbols are as defined above, with carbon monoxide and an alcohol represented by formula (3): [in-line-formulae]R3—OH ??(3)[/in-line-formulae]wherein the symbol is as defined above, in the presence of a transition metal complex catalyst containing at least one bidentate phosphine ligand and a base to thereby obtain the compound represented by formula (1).

Preparation method of alpha-fluorinated acrylate

The invention discloses a method for preparing alpha-fluorinated acrylate.The method comprises the steps that raw materials are dissolved into a first organic solvent at first, organic base or inorganic base is added, a hydroxyl protecting agent is added dropwisely on the condition of low temperature ranging from subzero 10 DEG C to 10 DEG C, the temperature is slowly increased to the room temperature to 100 DEG C after dropwise addition is completed, a heat preservation reaction is performed for 3-6 h, water is added for dissolving solids for organic phase washing and liquid separation, an organic phase is concentrated to be dry, the product is added into a second organic solvent, a polymerization inhibitor is added, heating is performed to reach 100-180 DEG C, a reaction is performed for 1-18 h, a mixed solution containing the product is distilled out, and then distillation purification is performed to obtain the alpha-fluorinated acrylate.The method is low in cost, easy to implement and low in equipment requirement, no extremely toxic substance is adopted as raw materials, the whole process is environmentally friendly, the yield is high, the product purity is good, and the method has economic value and is suitable for industrialization.

Method for the preparation of compounds

The invention provides a preparation method of a compound as described in the formula 1. The method comprises the steps of (1) contacting a compound as described in the formula 2 and a compound as described in the formula 3 in the existence of alkali to obtain a compound as described in the formula 4; and (2) directly contacting a reaction product obtained in the step (1) and paraformaldehyde to obtain the compound as described in the formula 1, wherein weak acid is added in the reaction product before the reaction product obtained in the step (1) is in contact with the paraformaldehyde so that the residual alkali in the reaction product can be neutralized. By using the method, the compound as described in the formula 1 can be effectively prepared.

Α, α-difluoropropionic production of esters

PROBLEM TO BE SOLVED: To provide a practical method of producing α,α-difluoro esters important as pharmaceutical and agricultural chemical intermediates. SOLUTION: The α,α-difluoro esters are produced by reacting α-halogeno-α-fluoro esters with salts or complexes comprising an organic base and hydrogen fluoride. Dehydrohalogenation of side reaction is controlled in the production method. Only α-fluoro-α,β-unsaturated esters of by-products are treated to be brought specifically into a high boiling-point, a boiling point difference gets remarkably large thereby between the α,α-difluoro ester of an objective product and the unsaturated ester of by-product, and a high purity product of the objective product is efficiently obtained by fractional distillation of a simple operation. The method is the practical method of producing the α,α-difluoro esters capable of solving a problem point in a prior technique. COPYRIGHT: (C)2012,JPOandINPIT

Designer HF-Based fluorination reagent: Highly regioselective synthesis of fluoroalkenes and gem -difluoromethylene compounds from alkynes

Hydrogen fluoride (HF) and selected nonbasic and weakly coordinating (toward cationic metal) hydrogen-bond acceptors (e.g., DMPU) can form stable complexes through hydrogen bonding. The DMPU/HF complex is a new nucleophilic fluorination reagent that has high acidity and is compatible with cationic metal catalysts. The gold-catalyzed mono- and dihydrofluorination of alkynes using the DMPU/HF complex yields synthetically important fluoroalkenes and gem-difluoromethlylene compounds regioselectively.

Preparation of substituted 2-fluoroacrylic acid derivatives

The present invention relates to a process for the preparation of substituted 2-fluoroacrylic acid derivatives.

Expedient synthesis of α-substituted fluoroethenes

A mild and efficient synthesis of 1-aryl-1-fluoroethenes from benzothiazolyl (aryl)fluoromethyl sulfones and paraformaldehyde, under DBU- or Cs2CO3-mediated conditions at room temperature, is described. A comparable diethyl fluoro(naphthalen-2-yl)methylphosphonate reagent does not react with paraformaldehyde under these mild conditions. The utility of the methodology for synthesis of terminal α-fluoroalkenes bearing electron-withdrawing functionalities is also shown.

Process for Preparation of 2-Fluoroacrylic Esters

According to the present invention, there is provided a production process of a 2-fluoroacrylic ester including: a bromination step of converting a 2-fluoropropionic ester to a 2-bromo-2-fluoropropionic ester by reaction of the 2-fluoropropionic ester with a nitrogen-bromine bond-containing brominating agent in the presence of a radical initiator; and a dehydrobromination step of reacting the 2-bromo-2-fluoropropionic ester with a base. It is not necessary in this process to adopt very-low-temperature conditions and to use a stoichiometric amount of expensive reagent. The target 2-fluoroacrylic ester can be thus produced at low cost.

Low-temperature 19F NMR spectroscopy of 1-fluoro-1-lithioethenes - Stability, shifts and unexpected coupling constants

Half-lives and fluorine atom shifts of stabilized 1-fluoro-l-lithioethenes bearing hydrogen, fluorine, phenyl, and/or dimethylphenylsilyl groups in the β-positions have been determined by a low-temperature 19F NMR spectroscopy. Some 1-fluoro-1-lithioethenes displayed an exceptionally low value of the trans-3JFF coupling constant. Stereoselectivity of carbenoid formation, as well as an effect of configuration on the stability is discussed.