76006-25-2

Usage

Amine substitution at the 7-position

The amine group (-NH2) is attached to the 7th position of the pyrazolo[3,4-c]pyridine ring, which is an important structural feature for its potential applications.

Phenyl group attached to the nitrogen atom

A phenyl group (-C6H5) is attached to the nitrogen atom in the amine group, which may influence the compound's biological activity and properties.

Potential applications in pharmaceutical research

Due to its interesting structural features, 1H-Pyrazolo[3,4-c]pyridin-7-amine, N-phenylmay exhibit biological activity, making it a candidate for further study in the development of new drugs.

Building block in the synthesis of other chemical compounds

1H-Pyrazolo[3,4-c]pyridin-7-amine, N-phenyl- can be used as a starting material or intermediate in the synthesis of other chemical compounds for various purposes, making it a versatile chemical.

Versatile chemical

1H-Pyrazolo[3,4-c]pyridin-7-amine, N-phenylhas potential applications in the field of medicinal chemistry and beyond, due to its unique structure and properties.

Upstream product

• 76006-11-6 7-chloro-1H-pyrazolo<3,4-c>pyridine 
• 62-53-3 aniline 
• 23056-39-5 2-chloro-3-nitro-4-methylpyridine 
• 76006-10-5 7-methoxy-1H-pyrazolo<3,4-c>pyridine 
• 76006-00-3 3-acetamido-2-chloro-4-methylpyridine 
• 76005-98-6 3-acetamido-2-methoxy-4-methylpyridine 
• 76006-12-7 1H-pyrazolo<3,4-c>pyridine-7(6H)-thione 
• 76006-09-2 1H-pyrazolo<3,4-c>pyridin-7(6H)-one 
• 76005-99-7 2-methoxy-3-amino-4-methylpyridine 
• 133627-45-9 3-Amino-2-chloro-4-methylpyridine 

Relevant academic research and scientific papers

The discovery of new cytotoxic pyrazolopyridine derivatives

A number of new 3,7-disubstituted pyrazolo[3,4-c]pyridines have been designed and synthesized from suitable 2-aminopyridines. The antiproliferative activity of the derivatives was determined against the pancreatic MIA PaCa-2 and ovarian SCOV3 cancer cell-lines. IC50values of the most promising analogue 46 lie in the submicromolar or low micromolar range. Furthermore, compound 46 shows similar inhibitory activities against DU145, A2058 and PC-3 cancer cells, blocks the cell cycle at the G0/G1phase and induce apoptosis, as determined by the appearance of apoptotic nuclei.

Pyrazolopyridines. Part 5. Preparation and Reactions of Pyrazolopyridines

A series of pyrazolopyridines has been prepared by nitrosation of 3-acetamido-4-methylpyridines and subsequent rearrangement and cyclisation of the N-acetyl-N-nitroso-compounds produced.The reactions of the pyrazolopyridines have been investigated. 1- and 2-Acetyl and 1- and 2-benzyl compounds were obtained and their structures elucidated spectroscopically.The ring system readily undergoes electrophilic substitution in the 3-position. 7-Chloropyrazolopyridine has been shown to be more susceptible to nucleophilic substitution than the isomeric 5-chloro-compound.