760177-69-3

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 496-69-5 2-bromo-4-fluoro-phenol 

Downstream Products

• 760177-70-6 5-fluoro-2-(tetrahydropyran-2-yloxy)-benzeneboronic acid 
• 1202677-46-0 5-fluoro-4'-(quinolin-2-ylmethoxy)biphenyl-2-yl trifluoromethanesulfonate 
• 1202661-39-9 2-(5'-fluoro-2'-pyridin-4-yl-biphenyl-4-yloxymethyl)-quinoline 
• 1202676-34-3 2-(4'-fluoro-2'-pyridin-4-yl-biphenyl-4-yloxymethyl)-quinoline 
• 1202677-45-9 5-fluoro-4'-(quinolin-2-ylmethoxy)-biphenyl-2-ol 
• 1202677-43-7 trifluoro-methanesulfonic acid 4-fluoro-2-pyridin-4-yl-phenyl ester 
• 1214338-37-0 4-fluoro-2-(pyridin-4-yl)phenol 
• 1202677-42-6 4-(5-fluoro-2-(tetrahydropyran-2-yloxy)-phenyl)-pyridine 
• 663619-15-6 (5-fluoro-2-hydroxy-phenyl)-oxo-acetic acid ethyl ester 
• 1202677-44-8 2-(5'-fluoro-2'-(tetrahydropyran-2-yloxy)-biphenyl-4-yloxymethyl)-quinoline 

Relevant academic research and scientific papers

Cascade Claisen and Meinwald Rearrangement for One-Pot Divergent Synthesis of Benzofurans and 2 H-Chromenes

A new cascade approach has been developed for the one-pot four-step divergent synthesis of polysubstituted benzofurans and 2H-chromenes, featuring a novel cascade aromatic Claisen rearrangement/Meinwald rearrangement/dehydrative or oxidative cyclization. This new method was demonstrated with 39 examples tolerating different substitutions at an epoxide, allylic ether, and aromatic ring, and we showcased its utility with the first total synthesis of natural product liparacid A in seven steps.

Enantioselective (3+2) cycloaddition: Via N-heterocyclic carbene-catalyzed addition of homoenolates to cyclic N -sulfonyl trifluoromethylated ketimines: Synthesis of fused N-heterocycle γ-lactams

An enantioselective (3+2) cycloaddition of enals and cyclic N-sulfonyl trifluoromethyl ketimines via N-heterocyclic carbene-catalyzed homoenolate addition is described. This reaction can efficiently construct fused N-heterocycle γ-lactams bearing two adjacent chiral centers with >20?:?1 dr and 94-99% ee, with one chiral center as a trifluoromethylated α-tetrasubstituted carbon stereocenter.

DI-SUBSTITUTED PHENYL COMPOUNDS

Di-substituted phenyl compounds which are inhibitors of phosphodiesterase 10 are described as are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) f

METAL COMPLEXES

The invention relates to novel metal complexes. Said compounds are used as active components (= functional materials) in a series of different applications which can be attributed in the broadest sense to the electronics industry. The compounds according to the invention are described by structure 1 and formulae 1 to 82.