Organic Letters p. 3004 - 3009 (2020)
Update date:2022-08-04
Topics: One-Pot Divergent Synthesis
Song, Liyan
Su, Qian
Lin, Xi
Du, Zhihui
Xu, Huiyou
Ouyang, Ming-An
Yao, Hongliang
Tong, Rongbiao
A new cascade approach has been developed for the one-pot four-step divergent synthesis of polysubstituted benzofurans and 2H-chromenes, featuring a novel cascade aromatic Claisen rearrangement/Meinwald rearrangement/dehydrative or oxidative cyclization. This new method was demonstrated with 39 examples tolerating different substitutions at an epoxide, allylic ether, and aromatic ring, and we showcased its utility with the first total synthesis of natural product liparacid A in seven steps.
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