760192-05-0

Upstream product

• 88-73-3 2-Chloronitrobenzene 
• 96-96-8 4-methoxy-2-nitroaniline 
• 5344-78-5 4-bromo-3-nitroanizole 
• 88-74-4 2-nitro-aniline 
• 58755-70-7 1-iodo-4-methoxy-2-nitrobenzene 

Downstream Products

• 4190-95-8 2-hydroxyphenazine 
• 2876-18-8 2-methoxyphenazine 
• 851331-09-4 N-(2-aminophenyl)-4-methoxybenzene-1,2-diamine 

Relevant academic research and scientific papers

Efficient methods for the synthesis of 2-hydroxyphenazine based on the Pd-catalyzed N-arylation of aryl bromides

(Chemical Equation Presented) Substituted diphenylamines can be synthesized by Pd(0)-catalyzed N-arylation using o-nitroanilines and nitro-substituted aryl bromides for a substrate. Cyclization of the diphenylamines by various methods, including the intramolecular Pd(0)-catalyzed N-arylation, produces 2-methoxyphenazine which can easily be deprotected to give 2-hydroxyphenazine. This phenazine is required to synthesize methanophenazine, a novel redoxactive cofactor isolated from methanogenic archaea.