76043-70-4Relevant academic research and scientific papers
ω-SUBSTITUTED α,α-DICHLOROALDEHYDES AND DERIVATIVES VIA FORMOLYSIS OR ACETOLYSIS OF 2,3,3-TRICHLOROTETRAHYDROFURAN AND 2,3,3-TRICHLOROTETRAHYDROPYRAN
Buyck, Laurent de,Vanhulle, Peter
, p. 329 - 336 (2007/10/02)
Preferable routes to the 2-hydroxyderivatives 7 resp. 8 of 2,3,3-trichloroTHF (1) or 2,3,3-trichloroTHP (2) involve the uncatalyzed methanolysis of the corresponding 2-formates or 2-acetates.These activated esters were rapidly formed from 1 or 2 in a hot
2,2-DICHLOROALDEHYDES FROM ALDEHYDES AND ALCOHOLS BY CHLORINATION IN DIMETHYLFORMAMIDE
Buyck, L. De,Verhe, R.,Kimpe, N. De,Courtheyn, D.,Schamp, N.
, p. 441 - 458 (2007/10/02)
A method is described for the synthesis of α,α-dichloroaldehydes, free from monochloroaldehyde, by chlorination of aldehydes or alcohols in dimethylformamide at 40-90 deg C.Results are reported for : (yield percent) propanal (90), butanal (78), pentanal (78), 3-methylbutanal (90), propanol (64), butanol (78), 3-methylbutanol (52), pentanol (66), 3,3-dimethylbutanol (86), hexanol (66), 2-phenylethanol (51), 3-phenylpropanol (54), 1,5-pentanediol , 1,6-hexanediol .Oxidative conversion (KMnO4, K2Cr2O7, H2O2-NaHCO3) into α,α-dichlorocarboxylic acids and methyl esters is discussed.
