76066-27-8 Usage
Uses
Used in Pharmaceutical Industry:
1-(Aminomethyl)cyclopentanol hydrochloride is used as an intermediate in the synthesis of various pharmaceutical compounds. Its application is primarily due to its ability to inhibit the enzyme phenylethanolamine N-methyltransferase (PNMT), which plays a crucial role in the biosynthesis of certain neurotransmitters and hormones. By inhibiting PNMT, 1-(aminomethyl)cyclopentanol hydrochloride can potentially be used in the development of drugs for the treatment of various neurological and cardiovascular disorders.
Additionally, 1-(aminomethyl)cyclopentanol hydrochloride is used as a starting material for the preparation of sulfonyl benzimidazole derivatives. These derivatives have been found to be useful in the treatment of diseases mediated by the CB2 receptor, which is a target for various therapeutic applications, including inflammation, pain, and neurodegenerative disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 76066-27-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,0,6 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 76066-27:
(7*7)+(6*6)+(5*0)+(4*6)+(3*6)+(2*2)+(1*7)=138
138 % 10 = 8
So 76066-27-8 is a valid CAS Registry Number.
76066-27-8Relevant academic research and scientific papers
HIV PROTEASE INHIBITORS
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Paragraph 0564; 0565, (2017/08/26)
The present invention is directed to 2,6-morpholine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein Z1, Z2, V1, V2, V3, R6, R6A, and X are defined herein. The invention also relates to methods of using the 2,6-morpholine derivatives of the invention for the inhibition of HV protease, the inhibition of HV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
BENZAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
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Paragraph 0523; 05411; 05412, (2014/03/25)
The invention relates to benzamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, n and Y are as defined in the description, their preparation and their use as pharmaceutically active compounds.
