76075-79-1

Usage

Explanation

This is the chemical name of the compound, which is also known as fenofibric acid.

Explanation

It is a synthetically produced compound that belongs to the carboxylic acid class of chemicals.

Explanation

Fenofibric acid is derived from fibric acid, which is another class of lipid-regulating agents.

Explanation

The main purpose of using fenofibric acid is to reduce cholesterol and triglyceride levels in the blood.

Explanation

Fenofibric acid works by activating peroxisome proliferator-activated receptor alpha (PPARα), a receptor that regulates lipid metabolism.

Explanation

By activating PPARα, fenofibric acid increases the metabolism of fatty acids and reduces the production of triglycerides in the body.

Explanation

Fenofibrate is the prodrug form of fenofibric acid, which is commonly prescribed to patients for managing hyperlipidemia.

Explanation

Fenofibrate is used to treat hyperlipidemia (high levels of lipids in the blood) and to reduce the risk of cardiovascular events, such as heart attacks and strokes.

Explanation

Although not mentioned explicitly in the material, fenofibric acid may cause side effects, such as gastrointestinal issues, muscle pain, or elevated liver enzymes, among others.

Classification

Synthetic carboxylic acid

Derivative

Fibric acid

Primary use

Lowering cholesterol and triglyceride levels

Mechanism of action

Activation of PPARα

Effect on metabolism

Increase in fatty acid metabolism, decrease in triglyceride production

Common form

Fenofibrate

Medical use

Managing hyperlipidemia, reducing cardiovascular risk

Potential side effects

Various side effects may occur

InChI:InChI=1/C11H13ClO3/c1-7(2)10(11(13)14)15-9-5-3-8(12)4-6-9/h3-7,10H,1-2H3,(H,13,14)

Upstream product

• 63403-20-3 α-(4-chlorophenoxy)-isovaleric acid ethyl ester 
• 10323-40-7 2-bromoisovaleric acid 
• 106-48-9 4-chloro-phenol 
• 609-12-1 ethyl 2-bromoisovalerate 
• 1193-00-6 sodium 4-chlorophenolate 

Downstream Products

• 63403-01-0 α-(4-chlorophenoxy)-isovaleric acid α'-allyl-3'-phenoxybenzyl ester 
• 63403-03-2 α-(4-chlorophenoxy)-isovaleric acid α'-vinyl-3'-phenoxybenzyl ester 
• 63403-06-5 2-(4-Chloro-phenoxy)-3-methyl-butyric acid 1-(3-phenoxy-phenyl)-propyl ester 
• 63403-05-4 α-(4-chlorophenoxy)-isovaleric acid α'-isopropyl-3'-phenoxybenzyl ester 
• 63402-99-3 α-(4-chlorophenoxy)-isovaleric acid α'-tert.butyl-3'-phenoxybenzyl ester 
• 4878-25-5 2-(4-Chloro-phenoxy)-3-methyl-butyryl chloride 
• 58327-21-2 2-(4-Chloro-phenoxy)-3-methyl-butyric acid 3,3,5-trimethyl-cyclohexyl ester 
• 67679-29-2 2-(4-Chloro-phenoxy)-3-methyl-butyric acid cyano-(3-phenoxy-phenyl)-methyl ester 
• 63402-73-3 α-(4-chlorophenoxy)-isovaleric acid 3'-phenoxybenzyl ester 

Relevant academic research and scientific papers

Quantitative structure activity relationship studies in pyrethroid esters derived from substituted 3-methyl-2-phenoxybutanoic acids against Culex quinquefasciatus

QSAR studies in relation to three physicochemical substituent parameters, lipophilicity, electronic and steric factors have been carried out with pyrethroid esters derived from substituted 3-methyl-2-phenoxybutanoic acids against Culex quinquefasciatus applying multiple regression analysis by grouping the esters into three based on their alcohol moiety. In the case of 3-phenoxybenzyl and α-cyano-3-phenoxybenzyl esters the larvicidal activity is mainly influenced by the lipophilic and electronic nature of the substituent at 4-position of the phenyl ring of the acid moiety. For adulticidal activity the lipophilicity of the substituent at 4-position followed by that of the substituents at 2-and 3-positions along with the steric effect are the important factors for 3-phenoxybenzyl and α-cyano-3-phenoxybenzyl esters. The larvicidal and adulticidal activities of 3,4-methylenedioxybenzyl esters are influenced by electronic factor followed by steric effect of the substituent.

Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 2. 2-Phenoxy-, 2-(phenylthio)-, and 2-(phenylamino)alkanoic acid esters

Further modifications of the leads ((R)-(+)-hyoscyamine and (p- chlorophenyl)propionic acid α-tropanyl ester), which show analgesic and nootropic activities as a consequence of increased central presynaptic ACh release, are reported. 2-Phenoxy- and 2-(phenylthio)alkanoic acid esters showed the best results. Several members of these classes possess analgesic properties which are comparable to that of morphine and at the same time are able to reverse dicyclomine-induced amnesia. Confirmation was found that the mechanism of action is due to an increase in ACh release at central muscarinic synapses and that both auto- and heteroreceptors controlling ACh release are very likely involved. According to the results obtained with (R)- (+)-hyoscyamine, analgesic activity is stereochemistry dependent, since the R-(+)-enantiomers are always more efficacious than the corresponding S-(-)- ones. On the basis of their potency and acute toxicity, compounds (±)-28 (SM21) and (±)-42 (SM32) were selected for further study.

2,3-Isopropylidene ribonic acid, 1,4-lactones

Racemic carboxylic acids are resolved into their enantiomers using optically active enantiomers of four lactones as resolving agents. The four lactones are 2,3-isopropylidene-ribonic acid-1,4-lactone, 1,2-isopropylideneglucofuranurono-3,6-lactone, 2-hydroxy-3,3-dimethyl-1,4-butyrolactone and 3,4-isopropylidene-arabino-1,5-lactone. Novel diastereoisomeric esters of the acids with the lactones are disclosed.