76081-98-6 Usage
Uses
Used in Pharmaceutical Industry:
2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE is used as a potent inhibitor of H+,K+-ATPase for the treatment of gastric acid-related disorders. It works by blocking acid secretion in the stomach, providing relief from symptoms associated with excess stomach acid.
Used in Research Applications:
2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE is used as a research tool to investigate the role of H+/K+-ATPases in various biological processes. It helps researchers understand the function and regulation of these enzymes in both mammalian and non-mammalian organisms.
Used in Drug Development:
2-METHYL-8-(PHENYLMETHOXY)IMIDAZO[1,2-A]PYRIDINE-3-ACETONITRILE is used as a lead compound in the development of new drugs targeting H+/K+-ATPases. Its unique mechanism of action and selectivity make it a valuable starting point for designing more effective and targeted therapies for acid-related disorders.
Biological Activity
Potent inhibitor of H + ,K + -ATPase (IC 50 = 20 nM); binds to the K + recognition site and is competitive with respect to K + . Inhibits gastric acid secretion in vitro and in vivo .
Biochem/physiol Actions
SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC50s of 2.5 and 4.0 μM respectively. SCH 32651 was less potent exhibiting an IC50 of 200.0 μM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase.
Check Digit Verification of cas no
The CAS Registry Mumber 76081-98-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,0,8 and 1 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 76081-98:
(7*7)+(6*6)+(5*0)+(4*8)+(3*1)+(2*9)+(1*8)=146
146 % 10 = 6
So 76081-98-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3
76081-98-6Relevant academic research and scientific papers
Skin Lightening Compositions
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, (2011/08/02)
Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure: or having the structure: as defined herein.
IMIDAZO(1,2-a)(PYRIDAZINES OR PYRAZINES) FOR TREATMENT OF DISEASES RELATED TO BONE LOSS
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, (2008/06/13)
A method for the treatment of diseases related to loss of bone mass such as osteoporosis, Paget's disease of bone, hy-perparathyroidism, malignant neoplasms causing hypercalcinemia, parodontal diseases and implant-related bone loss comprising administration to a patient suffering thereform an amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.
Antinuclear Agents. 1. Gastric Antisecretory and Cytoprotective Properties of Substituted Imidazopyridines
Kaminski, James J.,Bristol, James A.,Puchalski, Chester,Lovey, Raymond G.,Elliott, Arthur J.,et al.
, p. 876 - 892 (2007/10/02)
A novel class of antinuclear agents, the substituted imidazopyridines, is described.The present compounds are not histamine (H2) receptor antagonists nor are they prostaglandin analoques, yet they exhibit both gastric antisecretory and c
Imidazo[1,2-A]pyridines and use
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, (2008/06/13)
This invention relates to imidazo[1,2-a]pyridine derivatives which are useful in the treatment of peptic ulcer diseases.
