76088-45-4

Basic information

• Product Name: Benzothiazole, 2-(3,4,5-trimethoxyphenyl)-
• CAS NO: 76088-45-4
• Molecular Formula: C16H15NO3S
• Molecular Weight: 301.366
• Mol File: 76088-45-4.mol
• Article Data: 45

Chemical Properties

• CAS DataBase Reference: Benzothiazole, 2-(3,4,5-trimethoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzothiazole, 2-(3,4,5-trimethoxyphenyl)-(76088-45-4)
• EPA Substance Registry System: Benzothiazole, 2-(3,4,5-trimethoxyphenyl)-(76088-45-4)

Safety Data

• Hazardous Substances Data: 76088-45-4(Hazardous Substances Data)

Upstream product

• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 137-07-5 2-amino-benzenethiol 
• 95-16-9 1,3-Benzothiazole 
• 25245-29-8 5-iodo-1,2,3-trimethoxybenzene 
• 3840-31-1 (3,4,5-trimethoxyphenyl)methanol 
• 6443-69-2 3,4,5-trimethoxytoluene 
• 615-43-0 2-iodophenylamine 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 13400-02-7 3,4,5-trimethoxy styrene 
• 1239970-43-4 C₃₂H₃₂N₂O₆S₂ 
• 118-41-2 Eudesmic acid 
• 50606-35-4 3-(3',4',5'-trimethoxyphenyl)-3-oxopropanenitrile 
• 3044-56-2 ethyl trimethoxybenzoyl acetate 
• 457923-26-1 3,4,5-trimethoxybenzoic acid naphthalene-2-yl ester 

Relevant articles and documents

Ionic-Liquid-Catalyzed Synthesis of Imines, Benzimidazoles, Benzothiazoles, Quinoxalines and Quinolines through C?N, C?S, and C?C Bond Formation

We report the tetramethyl ammonium hydroxide catalyzed oxidative coupling of amines and alcohols for the synthesis of imines under metal-free conditions by utilizing oxygen from air as the terminal oxidant. Under the same conditions, with ortho-phenylene diamines and 2-aminobenzenethiols the corresponding benzimidazoles and benzothiazoles were obtained. Quinoxalines were obtained from ortho-phenylene diamines and 1-phenylethane-1,2-diol, the conditions were then extended to the synthesis of quinoline building blocks by reaction of 2-amino benzyl alcohols either with 1-phenylethan-1-ol or acetophenone derivatives. The formation of C?N, C?S and C?C bonds was achieved under metal-free conditions. A broad range of amines (aromatic, aliphatic, cyclic and heteroaromatic) as well as benzylic alcohols including heteroaryl alcohols reacted smoothly and provided the desired products. The mild reaction conditions, commercially available catalyst, metal-free, good functional-group tolerance, broad range of products (imines, benzimidazoles, benzothiazoles, quinoxalines and quinolines) and applicability at gram scale reactions are the advantages of the present strategy.

Camphor sulfonic acid catalyzed a simple, facile, and general method for the synthesis of 2-arylbenzothiazoles, 2-arylbenzimidazoles, and 3H-spiro[benzo[d]thiazole-2,3′-indolin]-2′-ones at room temperature

A simple, mild, eco-friendly, general, and convenient approach has been developed for the synthesis of structurally diverse 2-arylbenzothiazole derivatives from the reactions of 2-aminothiophenol and various aromatic aldehydes using camphor sulfonic acid

Preparation method of substituted benzothiazole C2 arylated derivative

The invention discloses a substituted benzothiazole C2 arylated derivative and a preparation method thereof. The preparation method comprises the following steps: mixing substituted benzothiazole represented by a formula (II) and substituted benzaldehyde represented by a formula (III); adding a free radical initiator N-chlorosuccinimide (NCS) and an oxidant tert-butyl hydroperoxide (TBHP), carrying out a stirring reaction for about 12 h at 120 DEG C in a nitrogen atmosphere by using DMSO as a solvent, and after the reaction is finished, separating and purifying the reaction liquid to prepare the substituted benzothiazole C2 arylated derivative represented by a formula (I). The invention provides a new method for synthesizing a benzothiazole C2 arylated derivative by taking an NCS/TBHP double component as an oxidation system through a stirring and reaction for about 12 hours at 120 DEG C in a nitrogen atmosphere under the assistance of a strong Lewis base DMSO; and according to the method, an NCS/TBHP double-component oxidation system and an aprotic solvent are selected, and the method has the advantages of being simple in catalytic system, good in product yield and wide in substrate range.