760983-17-3Relevant academic research and scientific papers
Oxazolidine-2-thiones: A molecular modeling study
Gandhi, Neha,Srivastava, Brijesh K.,Lohray, Vidya B.,Lohray, Braj B.
, p. 6269 - 6272 (2007/10/03)
Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding. Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding.
