760993-23-5Relevant academic research and scientific papers
1,4-Dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Extended exploration on phenyl ring substitutions and preliminary ADME/PK studies
Tong, Yunsong,Claiborne, Akiyo,Pyzytulinska, Magdalena,Tao, Zhi-Fu,Stewart, Kent D.,Kovar, Peter,Chen, Zehan,Credo, Robert B.,Guan, Ran,Merta, Philip J.,Zhang, Haiying,Bouska, Jennifer,Everitt, Elizabeth A.,Murry, Bernard P.,Hickman, Dean,Stratton, Tim J.,Wu, Jian,Rosenberg, Saul H.,Sham, Hing L.,Sowin, Thomas J.,Lin, Nan-horng
, p. 3618 - 3623 (2008/02/07)
A study on substitutions at the four open positions on the phenyl ring of the 1,4-dihydroindeno[1,2-c]pyrazoles as potent CHK-1 inhibitors is described. Bis-substitution at both the 6- and 7-positions led to inhibitors with IC50 values below 0.
Discovery of 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors
Tao, Zhi-Fu,Li, Gaoquan,Tong, Yunsong,Stewart, Kent D.,Chen, Zehan,Bui, Mai-Ha,Merta, Philip,Park, Chang,Kovar, Peter,Zhang, Haiying,Sham, Hing L.,Rosenberg, Saul H.,Sowin, Thomas J.,Lin, Nan-Horng
, p. 5944 - 5951 (2008/09/16)
An extensive structure-activity relationship study of the 3-position of a series of tricyclic pyrazole-based Chk1 inhibitors is described. As a result, 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles (4) and 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3
