76101-39-8

Upstream product

• 77245-04-6 C₅₇H₈₃N₄O₁₄PSi₃ 
• 3279-26-3 methyl dichlorophosphite 
• 87418-87-9 2',3'-bis-O-(tert-butyldimethylsilyl)uridine 
• 65109-15-1 2'-O-t-Butyldimethylsilyl-5'-O-monomethoxytrityl-N⁶-benzoyluridin 

Downstream Products

• 2415-43-2 uridylyl-3',5'-uridine 

Relevant academic research and scientific papers

NONAQUEOUS OXIDATION OF PHOSPHITES TO PHOSPHATES IN NUCLEOTIDE SYNTHESIS

m-Chloroperbenzoic acid in methylene chloride represents a rapid non-aqueous method for the conversion of phosphites to phosphates during oligonoucleotide synthesis both in solution and on a solid support.

The chemical synthesis of oligoribonucleotides. IX. A comparison of protecting groups in the dichloridite procedure

A series of phosphorodichloridites has been prepared incorporating the most commonly used phosphate protecting groups in oligonucleotide synthesis.The groups incude trichloroethyl, tribromoethyl, cyanoethyl, benzyl, methyl, p-chlorophenyl, and nitrophenetyl.The trichloroethyl and the nitrophenethyl appear to be the most stable groups while the cyanoethyl and methyl offer specific advantages.The benzyl and p-chlorophenyl groups are subject to limitations on their utility.Condensations can be carried out in a range of solvents incuding THF, pyridine, and DMF and at temperatures from -78 deg C to 20 deg C with a slight drop in yield with increasing temperature, at least for dinucleotide condensations.