76107-50-1Relevant academic research and scientific papers
PEGYLATED OPIOID WITH LOW ADDICTIVE EFFECT
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Paragraph 0069; 0072, (2018/12/13)
Provided in the present invention are a conjugate of polyethylene glycol and opioid as shown in general formula (I), and a pharmaceutical composition comprising the conjugate. By means of covalently bonding a plurality of opioids to a polyethylene glycol derivative, the present invention improves water solubility and pharmacokinetic property of the drug with a low addictive effect. ????????PEG-(X-OP)m?????(I)
Opiate receptor interaction of compounds derived from or structurally related to fentanyl
Lobbezoo,Soudijn,Van Wijngaarden
, p. 777 - 782 (2007/10/02)
The opiate receptor affinity of compounds derived from or structurally related to fentanyl (1) was determined by in vitro receptor binding assays. The relatively high affinity of fentanyl (3 times morphine) was hardly influenced by the introduction of a 2
Structure and receptor interactions of morphinomimetics. Part I. Hydroxy and methoxy derivatives of fentanyl and some morphine analogues
Lobbezoo,Soudijn,Van Wijngaarden
, p. 357 - 361 (2007/10/02)
The opiate receptor affinity of a number of fentanyl derivatives was determined by in vitro receptor binding studies and compared with that of morphine-like structures. The phenolic OH groups in morphine and in a benzomorphan derivative have a strong affi
