76117-70-9

Usage

Uses

Used in Oncology:
(E)-4-Acetoxy Tamoxifen is used as a chemosensitizing agent for overcoming breast cancer resistance protein (BCRP). This makes it a valuable tool in the treatment of breast cancer, as it can help to increase the effectiveness of chemotherapeutic drugs and potentially improve patient outcomes by enhancing drug sensitivity and overcoming drug resistance.

Upstream product

• 108-24-7 acetic anhydride 
• 68047-06-3 Z-1-<4-(2-dimethylaminoethoxy)phenyl>-1-(4-hydroxyphenyl)-2-phenyl-1-butene 
• 75-36-5 acetyl chloride 
• 68392-35-8 4-hydroxytamoxifen 

Relevant academic research and scientific papers

ERR MODULATORS AND USES THEREOF

Disclosed herein, inter alia, are compositions and methods useful for treating non-alcoholic fatty liver diseases.

Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4

Tamoxifen (TAM), a nonsteroidal antiestrogen, is the most widely used drug for chemotherapy of hormone-dependent breast cancer in women. Trans-4-hydroxy-TAM (trans-4-HO-TAM), one of the TAM metabolites in humans, has been considered to be an active metabo

Compounds and methods for treating breast cancer and other diseases

Disclosed are novel compositions and novel methods for the creation of both the novel compounds and known compounds. Also disclosed are methods for use of the novel compounds for treating a variety of diseases relating to decreasing or preventing activati