76132-45-1

Upstream product

• 5424-19-1 3-Benzoylpyridine 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 76132-51-9 (Z)-3-Phenyl-3-pyridin-3-yl-acrylamide 
• 1120-90-7 3-iodopyridine 
• 1885-38-7 cinnamic nitrile 
• 76132-51-9 (Z)-3-Phenyl-3-pyridin-3-yl-acrylamide 
• 184419-56-5 3-phenyl-3-pyridin-3-yl-acrylonitrile 

Relevant academic research and scientific papers

Stereospecific synthesis of 3,3-disubstituted acrylonitriles by Heck reaction

The coupling reaction of 3-aryl (or heteroaryl) acrylonitriles with several aryl and heteroaryl iodides (Heck reaction) under Jeffery's conditions has been studied as a concept to synthesize, in a stereospecific manner, trisubstituted olefins.

Highly efficient Rh-catalyzed asymmetric hydrogenation of α,β-unsaturated nitriles

A highly efficient enantioselective hydrogenation of α,β-unsaturated nitriles catalyzed by Rh-(R,R)-f-spiroPhos complex has been developed. With Rh-(R,R)-f-spiroPhos catalyst and under mild conditions, a wide range of α,β-unsaturated nitriles including the (E)- and (Z)-isomers of 3-alkyl-3-aryl, 3,3-diaryl, and 3,3-dialkyl α,β-unsaturated nitriles were hydrogenated to the corresponding chiral nitriles with excellent enantioselectivities (up to 99.9% ee) and high turnover numbers (TON up to 10,000).