761414-86-2

Basic information

• Product Name: 1H-Pyrazole-5-carbonitrile, 1-(chloroacetyl)-4,5-dihydro-, (5S)- (9CI)
• Synonyms: 1H-Pyrazole-5-carbonitrile, 1-(chloroacetyl)-4,5-dihydro-, (5S)- (9CI)
• CAS NO: 761414-86-2
• Molecular Formula: C6H6ClN3O
• Molecular Weight: 171.58434
• Product Categories: ACETYLHALIDE
• Mol File: 761414-86-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrazole-5-carbonitrile, 1-(chloroacetyl)-4,5-dihydro-, (5S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-5-carbonitrile, 1-(chloroacetyl)-4,5-dihydro-, (5S)- (9CI)(761414-86-2)
• EPA Substance Registry System: 1H-Pyrazole-5-carbonitrile, 1-(chloroacetyl)-4,5-dihydro-, (5S)- (9CI)(761414-86-2)

Safety Data

• Hazardous Substances Data: 761414-86-2(Hazardous Substances Data)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 761414-85-1 (S)-2-(2-Chloro-acetyl)-3,4-dihydro-2H-pyrazole-3-carboxylic acid amide 

Relevant articles and documents

Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents

A new series of cyano-pyrazoline derivatives with secondary amine at P-2 site was synthesized through achiral and chiral synthetic methods and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV). Compound 5i revealed good in vivo efficacy (ED50: 4.1mg/kg; in vivo DP-IV inhibition). Also chiral derivative (11b) having (S)-configuration of compound 5i was found to be more potent.