16288-77-0

Basic information

• Product Name: 2-AMINO-N-METHYLBENZENESULFONAMIDE
• Synonyms: 2-AMINO-N-METHYLBENZENESULFONAMIDE;2-amino-N-methylbenzenesulfonamide(SALTDATA: HCl);N-Methyl-2-aminobenzenesulfonamide;2-aMino-N-Methylbenzene-1-sulfonaMide;BenzenesulfonaMide, 2-aMino-N-Methyl-
• CAS NO: 16288-77-0
• Molecular Formula: C₇H₁₀N₂O₂S
• Molecular Weight: 186.23
• Mol File: 16288-77-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 59-60℃
• Boiling Point: 352.9 °C at 760 mmHg
• Flash Point: 167.2 °C
• Appearance: /
• Density: 1.308
• Vapor Pressure: 3.73E-05mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: 2-8°C(protect from light)
• PKA: 11?+-.0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-N-METHYLBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-METHYLBENZENESULFONAMIDE(16288-77-0)
• EPA Substance Registry System: 2-AMINO-N-METHYLBENZENESULFONAMIDE(16288-77-0)

Safety Data

• Hazardous Substances Data: 16288-77-0(Hazardous Substances Data)

Usage

General Description

2-Amino-N-methylbenzenesulfonamide is a chemical compound with the molecular formula C7H10N2O2S. It is a sulfonamide derivative containing an amino group and a methyl group attached to a benzene ring. 2-Amino-N-methylbenzenesulfonamide has been studied for its potential use in pharmaceutical applications, particularly as an antibiotic or antimicrobial agent due to its ability to inhibit the growth of certain bacteria. It may also have potential applications in the treatment of urinary tract infections and other medical conditions. Additionally, it is a water-soluble compound and is stable under normal storage conditions.

InChI:InChI=1/C7H10N2O2S/c1-9-12(10,11)7-5-3-2-4-6(7)8/h2-5,9H,8H2,1H3

Upstream product

• 90334-95-5 N-methyl-N-{(2-nitrophenyl)sulfonyl}acetamide 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 7781-47-7 2-acetylamino-benzenesulfonic acid methylamide 
• 23530-40-7 N-methyl-2-nitrobenzenesulfonamide 
• 854878-48-1 (2-amino-benzenesulfonyl)-methyl-carbamic acid ethyl ester 
• 58974-34-8 methyl-(2-nitro-benzenesulfonyl)-carbamic acid ethyl ester 
• 22819-25-6 ethyl ((2-nitrophenyl)sulfonyl)carbamate 

Downstream Products

• 1061358-64-2 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzenesulfonamide 
• 761440-11-3 2-((2-amino-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide 
• 761440-01-1 2-(5-bromo-2-chloro-pyrimidin-4-ylamino)-N-methyl-benzenesulfonamide 
• 761440-00-0 2-(2-chloro-5-nitro-pyrimidin-4-ylamino)-N-methyl-benzenesulfonamide 
• 1346447-84-4 N-(3-((5-chloro-4-((2-(N-methylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide 
• 1346447-83-3 2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide 
• 1346447-82-2 2-((5-chloro-2-((3-nitrophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide 
• 21639-21-4 2-methyl-3-phenyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-dioxide 

Relevant articles and documents

One-pot synthesis ofN-substituted benzannulated triazolesviastable arene diazonium salts

A mild and effective one-pot synthesis of 1,2,3-benzotriazin-4(3H)-ones and benzothiatriazine-1,1(2H)-dioxide analogues has been developed. The method involves the diazotisation and subsequent cyclisation of 2-aminobenzamides and 2-aminobenzenesulfonamidesviastable diazonium salts, prepared using a polymer-supported nitrite reagent andp-tosic acid. The transformation was compatible with a wide range of aryl functional groups and amide/sulfonamide-substituents and was used for the synthesis of pharmaceutically important targets. The synthetic utility of the one-pot diazotisaton-cyclisation process was further demonstrated with the preparation of an α-amino acid containing 1,2,3-benzotriazin-4(3H)-one.

COMPOUNDS THAT MODULATE EGFR ACTIVITY AND METHODS FOR TREATING OR PREVENTING CONDITIONS THEREWITH

Provided are compounds and methods for treating or preventing kinase-mediated disorders therewith.

PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I), wherein R1, R2, X1, X2 and n have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.