16288-77-0

Usage

Uses

Used in Pharmaceutical Applications:
2-Amino-N-methylbenzenesulfonamide is used as an antibiotic or antimicrobial agent for its ability to inhibit the growth of certain bacteria, making it a candidate for the development of new treatments against bacterial infections.
Used in Urinary Tract Infection Treatment:
2-Amino-N-methylbenzenesulfonamide is utilized in the treatment of urinary tract infections due to its potential antimicrobial properties, offering a new avenue for managing such conditions.
Used in Research and Development:
2-Amino-N-methylbenzenesulfonamide serves as a subject of research for exploring its potential applications in various medical conditions, given its chemical structure and properties that allow for interaction with biological systems.

InChI:InChI=1/C7H10N2O2S/c1-9-12(10,11)7-5-3-2-4-6(7)8/h2-5,9H,8H2,1H3

Upstream product

• 23530-40-7 N-methyl-2-nitrobenzenesulfonamide 
• 7781-47-7 2-acetylamino-benzenesulfonic acid methylamide 
• 854878-48-1 (2-amino-benzenesulfonyl)-methyl-carbamic acid ethyl ester 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 90334-95-5 N-methyl-N-{(2-nitrophenyl)sulfonyl}acetamide 
• 58974-34-8 methyl-(2-nitro-benzenesulfonyl)-carbamic acid ethyl ester 
• 22819-25-6 ethyl ((2-nitrophenyl)sulfonyl)carbamate 

Downstream Products

• 761440-00-0 2-(2-chloro-5-nitro-pyrimidin-4-ylamino)-N-methyl-benzenesulfonamide 
• 21639-21-4 2-methyl-3-phenyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-dioxide 
• 1346447-84-4 N-(3-((5-chloro-4-((2-(N-methylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide 
• 1346447-83-3 2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide 
• 1346447-82-2 2-((5-chloro-2-((3-nitrophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide 
• 1061358-64-2 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzenesulfonamide 
• 761440-11-3 2-((2-amino-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide 
• 761440-01-1 2-(5-bromo-2-chloro-pyrimidin-4-ylamino)-N-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

One-pot synthesis ofN-substituted benzannulated triazolesviastable arene diazonium salts

A mild and effective one-pot synthesis of 1,2,3-benzotriazin-4(3H)-ones and benzothiatriazine-1,1(2H)-dioxide analogues has been developed. The method involves the diazotisation and subsequent cyclisation of 2-aminobenzamides and 2-aminobenzenesulfonamidesviastable diazonium salts, prepared using a polymer-supported nitrite reagent andp-tosic acid. The transformation was compatible with a wide range of aryl functional groups and amide/sulfonamide-substituents and was used for the synthesis of pharmaceutically important targets. The synthetic utility of the one-pot diazotisaton-cyclisation process was further demonstrated with the preparation of an α-amino acid containing 1,2,3-benzotriazin-4(3H)-one.

2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS

The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/ or Pyk2 mediated disorder or disease.

COMPOUNDS THAT MODULATE EGFR ACTIVITY AND METHODS FOR TREATING OR PREVENTING CONDITIONS THEREWITH

Provided are compounds and methods for treating or preventing kinase-mediated disorders therewith.

Nickel-catalyzed regio- and enantioselective annulation reactions of 1,2,3,4-benzothiatriazine-1,1(2H)-dioxides with allenes

(Figure Presented) Extrusion of N2:1,2,3,4-Benzothiatriazine1,1 (2H)-dioxides reacted with alienes in the presence of a nickel (0)/(R)-quinap complex to produce a variety of substituted 3,4-dihydro-1,2-benzothiazine1,1 (2H)-dioxides in a regio- and enantioselective fashion. An intermediate nickelacycle was generated through denitrogenative activation of the triazo moiety which allowed the intermolecular incorporation of an aliene group. quinap = 1-(2diphenylphosphino-1-naphthyl)isoquinoline.

PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I), wherein R1, R2, X1, X2 and n have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

Imidazoline derivatives as alpha-1A adrenoceptor ligands

Compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed. Such compounds are useful in the treatment of Alpha-1A mediated diseases or conditions such as urinary incontinence.