761447-63-6

Usage

Uses

Used in Pharmaceutical Applications:
4-Bromo-2-(2-hydroxyprop-2-yl)-1,3-thiazole is used as a valuable intermediate for the synthesis of potentially bioactive molecules, contributing to the development of new drugs with therapeutic properties. Its unique structure allows for the creation of compounds that may address various medical needs.
Used in Agrochemical Development:
In the agrochemical industry, 4-Bromo-2-(2-hydroxyprop-2-yl)-1,3-thiazole is used as a key intermediate in the synthesis of compounds with pesticidal or herbicidal activity, potentially leading to the development of more effective and targeted agrochemicals.
Used in Materials Science:
4-Bromo-2-(2-hydroxyprop-2-yl)-1,3-thiazole is utilized as a component in the production of specialty chemicals, which may have applications in materials science for creating new materials with specific properties, such as improved stability or reactivity.
Used in Organic Synthesis:
As an intermediate in organic synthesis, 4-Bromo-2-(2-hydroxyprop-2-yl)-1,3-thiazole is used for the preparation of a variety of chemical compounds, expanding the scope of chemical research and development in multiple industries.

InChI:InChI=1/C6H8BrNOS/c1-6(2,9)5-8-4(7)3-10-5/h3,9H,1-2H3

Upstream product

• 4175-77-3 2,4-dibromo-1,3-thiazole 
• 67-64-1 acetone 

Downstream Products

• 1131736-48-5 5-[(4-acetyl-2,6-dichlorophenyl)amino]-9-[2-(1-hydroxy-1-methylethyl)-1,3-thiazol-4-yl]benzo[c]-2,6-naphthyridin-1(2H)-one 

Relevant academic research and scientific papers

Total synthesis of cystothiazoles A and B

(Chemical Equation Presented) Convergent enantioselective syntheses of the antifungal agents cystothiazoles A and B are described. The routes feature an asymmetric crotylation using a propargylic dicobalt hexacarbonyl complex, which provided enhanced diastereoselectivity over the uncomplexed propargylic acetal. The bisthiazole fragment was united with the side chain through a Stille cross-coupling of a terminal (E)-vinylstannane with a 4-trifloyl-substituted thiazole.

SUBSTITUTED BIPHENYL DERIVATIVE

The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: wherein R1 represents a C6-C10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C1-C6 alkyl)amino group, a di-(C1-C6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C1-C6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R3 represents a C1-C6 alkyl group, and so on; and R4 represents a C1-C6 alkyl group, and so on.