76146-32-2

Upstream product

• 4070-48-8 L-Valine methyl ester 
• 2768-53-8 N-benzyloxycarbonyl-L-alanyl-L-phenylalanine 
• 6306-52-1 L-valine methylester hydrochloride 
• 58091-14-8 N-(L)-valine methyl ester 
• 1142-20-7 N-Cbz-Ala 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 3235-14-1 (S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-3-phenyl-propionic acid methyl ester 

Downstream Products

• 1639120-80-1 Cbz-Ala-Phe-Val-Leu-OMe 
• 1639120-91-4 Cbz-Ala-Phe-D-Val-Leu-OMe 
• 244206-40-4 C₂₅H₃₁N₃O₆ 

Relevant academic research and scientific papers

ZUR REAKTION VON IMIDODITHIOCARBONATEN MIT CARBONSAUREN I: SYNTHESE DES MODELLPEPTID-DERIVATES Z-(L)-Ala-(L-D)-Phe-(L)-Val-OMe

The tripeptide derivative Z-(L)-Ala-(L/D)-Phe-(L)-Val-OMe was obtained in 4Opercent yield by reacting (CH3S)2C=N-(L)-CH--COOCH3with the dipeptide derivative Z-(L)-Ala(L)-Phe-OH and ZnCl2 at 110 deg C.The product obtained by bulk condensation con

A one-pot saponification-coupling sequence suitable for C-terminus peptide elongation using lithium carboxylates

An efficient procedure has been developed for the saponification of common peptide esters, followed by straightforward coupling of the lithium carboxylate. Adding some water to the reaction medium gave faster saponification and did not interfere with the coupling reagent. As peptide chemistry constitutes a major application of the amidation reaction, amino acid substrates were chosen for this study, monitoring both yields and epimerization of the peptides obtained. Georg Thieme Verlag Stuttgart New York.