76148-83-9Relevant academic research and scientific papers
Use of (Z)-β-(2-fluorobenzenesulfonyl)vinylamines as novel synthons in the synthesis of 1,4-benzothiazine derivatives
Tsui, Gavinchit,Singjunla, Yuttapong,Lautens, Mark
, p. 1359 - 1364 (2012/06/30)
A novel synthetic route for arylated 1,4-benzothiazine derivatives has been developed. This method utilizes a key intramolecular nucleophilic aromatic substitution step of the corresponding (Z) - (2-fluorobenzenesulfonyl)vinylamine intermediate to construct the benzothiazine ring. A wide range of aryl and heteroaryl substituent groups can be installed from commercial boronic acids. Both mono- and diarylated products have been synthesized in good yields and with good functional group tolerance. Georg Thieme Verlag Stuttgart · New York.
High yield synthesis of 4H-1,4-benzothiazine-1,1-dioxide derivatives
De Montis, Stefania,Fattuoni, Claudia,Cadoni, Enzo,Cabiddu, Maria G.,Usai, Michele,Cabiddu, Salvatore
experimental part, p. 1445 - 1449 (2009/04/07)
(Chemical Equation Presented) 4H-1,4-Benzothiazine-1,1-dioxide derivatives were synthesized through a sequence of almost quantitative reactions. The commercial starting material 2-(methylsulfanyl)aniline was Boc-protected, N-acylated and oxidized at the sulfur atom to obtain a sulfonyl derivative. An anionic transposition of the acyl group followed by a simultaneous deprotection-cyclization gave the title products in excellent yields. All products and intermediates were fully characterized.
New dyes based on 3-aryl-benzo- and -naphtho-1,4-thiazines
MacKenzie, Neil E.,Thomson, Ronald H.,Greenhalgh, Colin W.
, p. 2923 - 2932 (2007/10/02)
3-Aryl-2H-1,4-benzothiazines have been converted into cyanine dyes by condensing their hydroperchlorates with aldehydes, and into azo-compounds by coupling with reactive diazonium salts. The azo-compounds were also obtained by condensing arylglyoxal hydra
