76149-15-0

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-di-N-propylaminoethyl)indole is used as a pharmaceutical agent for its potential dopamine agonist activity. Its derivatives have been found to modulate dopamine receptors, which play a crucial role in the regulation of various physiological processes, including motor control, cognition, and mood regulation. 4-(2-di-N-propylaminoethyl)indole may be utilized in the development of treatments for neurological disorders such as Parkinson's disease, schizophrenia, and depression.
Used in Drug Delivery Systems:
4-(2-di-N-propylaminoethyl)indole can be employed as a component in drug delivery systems to enhance the bioavailability and therapeutic efficacy of other pharmaceutical agents. Its unique structural features may allow for the development of novel drug carriers, such as nanoparticles or liposomes, that can improve the delivery of drugs to target tissues and cells, thereby increasing their effectiveness and reducing side effects.
Used in Chemical Research:
As a member of the indole family, 4-(2-di-N-propylaminoethyl)indole can be used as a research tool in chemical and biological studies. Its unique structure and potential biological activities make it an interesting subject for investigations into the structure-activity relationships of indole-based compounds, as well as their interactions with various biological targets and pathways.
Used in Agrochemical Industry:
4-(2-di-N-propylaminoethyl)indole may also find applications in the agrochemical industry, where it could be used as a component in the development of novel pesticides or herbicides. Its unique structural features and potential biological activities may enable the design of new compounds with improved efficacy and selectivity, contributing to more sustainable and environmentally friendly agricultural practices.

InChI:InChI=1/C16H24N2/c1-3-11-18(12-4-2)13-9-14-6-5-7-16-15(14)8-10-17-16/h5-8,10,17H,3-4,9,11-13H2,1-2H3

Upstream product

• 31110-58-4 2-<(1-acetyl)-4-indolyl>acetaldehyde 
• 16176-73-1 2-(1H-indol-4-yl)ethan-1-amine 
• 107-08-4 1-iodo-propane 
• 49839-99-8 4-(2-nitrovinyl)indole 
• 1074-86-8 4-formyl indole 
• 32666-56-1 1-amino-5,8-dihydronaphthalene 
• 134-32-7 1-amino-naphthalene 
• 802294-64-0 propionic acid 
• 115348-05-5 1-acetamido-5,8-dihydronaphthalene 
• 84401-12-7 benzyl 1-benzoylindole-4-carboxylate 
• 84401-14-9 1-benzoyl-4-diazoacetylindole 
• 84401-13-8 1-benzoylindole-4-carboxylic acid 
• 344320-85-0 1-Benzoyl-1H-indole-4-carbonyl chloride 
• 84401-11-6 benzyl indole-4-carboxylate 

Downstream Products

• 91374-21-9 Ropinirole 

Relevant academic research and scientific papers

Synthesis of 2-Oxindoles from Substituted Indoles by Hypervalent-Iodine Oxidation

A practical conversion of indoles into the corresponding 2-oxindoles is achieved efficiently using a hypervalent iodine reagent. This oxidation is amenable to different substituted indoles, and allows the synthesis of a wide range of synthetically valuable substituted 2-oxindoles in up to 90 % yield. Furthermore, Ropinirole, a drug used to alleviate the symptoms of Parkinson's disease, was synthesized in three steps in an overall yield of 44 % using this method.

The development of a short route to the API ropinirole hydrochloride

A four-step, three-stage synthesis of the API ropinirole hydrochloride has been developed from a commercially available naphthalene derivative. The new route has half the step-count and twice the overall yield of the current manufacturing process. Key features of the synthesis are a regioselective Birch reduction and an ozonolysis with concomitant ring closure to induce the required ring contraction.

PROCESS FOR THE PREPARATION OF ROPINIROLE

A new process for the preparation of Ropinirole (1) and pharmaceutically acceptable hydrochloride salt thereof comprising reacting the compound V with nitromethane to obtain the compound of formula 11, which is reduced to compound III and alkylated to obtain compound IV. The oxidation of the indole ring provides the compound of formula (I).

Preparation of alkyl-substituted indoles in the benzene portion. Part 5. Efficient preparative procedure for 4-substituted indole derivatives

An effective and short synthetic method for 4-substituted indole derivatives was developed based on the two sequential reactions, i.e. nucleophilic addition of carbanions to common precursor molecules, 3-(1,3-dioxolan-2-yl)-1-[1(phenylsulfonyl)- and 1-[(4

Synthesis of N-Alkyl Derivatives of 4-(2'-Aminoethyl)indole

N-Substituted 4-(2'-aminoethyl)indoles are attainable in good yields from indole-4-acetic acid (2).Several methods of preparation for 2 were tried or considered.A new sequence involving Arndt-Eistert homologation of indole-4-carboxylic acid has been devis