76162-58-8

Upstream product

• 73501-02-7 5-(p-methoxyphenyl)-2-trichloromethyl-1,3,4-oxathiazole 
• 623-47-2 propynoic acid ethyl ester 
• 52533-09-2 5-(4-methoxyphenyl)-[1,3,4]oxathiazol-2-one 
• 73501-03-8 5-(p-methoxyphenyl)-2,2-bis(trichloromethyl)-1,3,4-oxathiazole 
• 73501-04-9 5-(p-methoxyphenyl)-2-phenyl-2-trifluoromethyl-1,3,4-oxathiazole 

Downstream Products

• 1204424-56-5 C₂₁H₂₄ClNO₇S 
• 1204424-55-4 3-[4-chloro-3-(4-methoxyphenyl)isothiazol-5-yl]propionic acid 
• 1204424-61-2 Triethyl 2-[4-bromo-3-(4-methoxyphenyl)isothiazol-5-yl]ethanetricarboxylate 
• 1204424-60-1 [4-Bromo-3-(4-methoxyphenyl)isothiazol-5-yl]methanol 
• 1204424-54-3 [4-Chloro-3-(4-methoxyphenyl)isothiazol-5-yl]methanol 
• 1204424-53-2 [3-(4-Methoxyphenyl)isothiazol-5-yl]methanol 
• 82424-95-1 3-(4-anisyl)-5-isothiazolecarboxylic acid 

Relevant academic research and scientific papers

NITROGEN-CONTAINING AROMATIC HETEROCYCLYL COMPOUND

The present invention provides a compound having excellent regulating action on blood lipid level. The present invention provides a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, etc., wherein A represents a 5-membered nitrogen-containing aromatic heterocyclyl group; R1 represents COOH or the like; each R2 represents an alkyl or the like; each R3 represents an optionally substituted phenyl, an optionally substituted phenylalkyl, or the like; m represents 0, 1, 2, or 3; n represents 0 or 1; each of R4, R5, R6, and R7 represents H, an alkyl, or the like; and B represents an optionally substituted naphthyl, an optionally substituted aromatic heterocyclyl, or a group represented by the following formula (II) wherein each of B1 and B2 represents an optionally substituted phenyl or an optionally substituted aromatic heterocyclyl.

Nitrile Sulphides. Part 3. Thermal Fragmentation of 1,3,4-Oxathiazoles: Formation of Nitrile Sulphides in a Retro-1,3-dipolar Cycloaddition Reaction

On thermolysis at ca. 160 gradC 1,3,4-oxathiazoles undergo retro-1,3-dipolar cycloaddition forming nitrile sulphides and carbonyl-containing fragments.The nitrile sulphides either decompose to sulphur and nitriles or are trapped as their 1,3-dipolar cycloadducts in the presence of dipolarophiles (dimethyl acetylenedicarboxylate, ethyl cyanoformate, benzonitrile, ethyl propiolate).Similar ratios (1.32, l.34, 1.33, 1.31) of 4- and 5-ethoxycarbonyl-3-(p-methoxyphenyl)isothiazole obtained from four sources of p-methoxybenzonitrile sulphide with ethyl propriolate provide strong evidence for product formation from a discrete intermediate nitrile sulphide rather than via direct interaction of precursor with dipolarophile. 2-Dichloromethylene-1,3,4-oxathiazoles, prepared by dehydrochlorination of 2-trichloromethyloxathiazoles, prepared by dehydrochlorination of 2-trichlorometyloxathiazoles, likewise fragment to nitrile sulphides, but attempts to trap dichloroketene were unsuccessful.

Nitrile Sulphide Formation from the Thermal Fragmentation of 1,3,4-Oxathiazoles: a Retro-1,3-dipolar Cycloaddition

1,3,4-Oxathiazoles, on thermolysis, undergo retro-1,3-dipolar cycloaddition to afford carbonyl compounds and nitrile sulphides, which may be trapped by cycloaddition with alkynes and nitriles.