7617-70-1

Upstream product

• 52062-92-7 4-(2-bromoethyl)benzoic acid 
• 24249-98-7 p-chloromethyl-2-bromoethylbenzene 
• 4885-02-3 Dichloromethyl methyl ether 
• 103-63-9 1-phenyl-2-bromoethane 
• 5312-73-2 dichloromethyl n-butyl ether 

Downstream Products

• 72054-56-9 4-(2-bromoethyl)benzonitrile 
• 1622143-73-0 1-(2-chloroethyl)-4-(dimethoxymethyl)benzene 
• 1622143-72-9 1-(2-bromoethyl)-4-(dimethoxymethyl)benzene 
• 934753-51-2 ethyl 8-(4-cyanophenyl)-6-formyloctanoate 
• 934737-83-4 methyl 4-[4-(4-cyanophenyl)-2-formylbutyl]benzoate 
• 934753-50-1 ethyl 8-(4-cyanophenyl)-6-hydroxymethyloctanoate 
• 934737-82-3 methyl 4-[4-(4-cyanophenyl)-2-hydroxymethylbutyl]benzoate 
• 934753-49-8 2-[2-(4-cyanophenyl)ethyl]heptanedioic acid 7-ethyl ester 
• 934737-81-2 methyl 4-[2-carboxy-4-(4-cyanophenyl)butyl]benzoate 
• 934753-05-6 methyl (E)-4-[2-[2-(4-cyanophenyl)ethyl]-4-(2-hydroxyphenyl)but-3-enyl]benzoate 
• 934753-52-3 ethyl E-6-[2-(4-cyanophenyl)ethyl]-8-(2-hydroxyphenyl)oct-7-enoate 
• 934753-48-7 1-Allyl 7-ethyl 2-allyloxycarbonyl-2-[2-(4-cyanophenyl)ethyl]heptandioate 
• 934737-79-8 diallyl 2-[2-(4-cyanophenyl)ethyl]-2-(4-methoxycarbonylbenzyl)malonate 
• 935253-25-1 Methyl 4-{(3E)-4-{2-[(2-chlorobenzyl)oxy]phenyl}-2-[2-(4-cyanophenyl)ethyl]but-3-en-1-yl}-benzoate 

Relevant academic research and scientific papers

KINASE MODULATORS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS

Provided herein are kinase modulators, e.g., a compound of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a disease, disorder, or condition associated with a protein malfunction.

Synthesis and characterization of new chitosan-based Schiff base compounds

Chitin (Cn) was extracted from the armors of crustaceans Astacus leptodactylus (Lake Sevan, Armenia) and then converted to chitosan (Cs), its deacetylated derivative. Novel Schiff bases (CsSB) were synthesized by interaction of Cs with 4-(2-chloroethyl)be

SUBSTITUTED DIARYL AZETIDINE DERIVATIVES AS SPHINGOSINE RECEPTOR MODULATORS

The present invention relates to substituted diaryl azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

SUBSTITUTED DIARYL DERIVATIVES AS SPHINGOSINE RECEPTOR MODULATORS

The present invention relates to substituted diaryl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

Aerobic oxidation of benzylic halides to carbonyl compounds with molecular oxygen catalyzed by tempo/kno2 in aqueous media

Benzylic halides were successfully oxidized to the corresponding aldehydes and ketones in good to excellent yields in aqueous media with molecular oxygen as oxidant in the presence of catalytic amounts of TEMPO (2,2,6,6- tetramethylpiperidyl-1-oxy) and potassium nitrite (KNO2).

Dicarboxylic Acid Derivatives and their Use

The present application relates to novel dicarboxylic acid derivatives, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, es

Heterocyclic compounds with carboxyl isostere groups and their use for the treatment of cardiovascular diseases

The present application relates to novel heterocyclic compounds, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especia

Tetrazole Derivatives and Their Use for the Treatment of Cardiovascular Diseases

The present application relates to novel tetrazole derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especial

2-AMINOPROPANE-1,3-DIOL COMPOUNDS, MEDICINAL USE THEREOF, AND INTERMEDIATES IN SYNTHESIZING THE SAME

The present invention relates to a compound of the general formula wherein R1, R2, R3 and R4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof; a pharmaceutical comprising this compound; a pharmaceutical composition comprising this compound and a pharmaceutically acceptable carrier; and 2-amino-2-(2-(4-(1-hydroxy-5-phenylpentyl)phenyl)ethyl)propane-1,3-diol or 2-amino-2-(2-(4-formylphenyl)ethyl)propane-1,3-diol, the derivatives of the two compounds whose amino group and/or hydroxy group are(is) protected or a salt thereof. The compound of the present invention shows superior immunosuppressive action with less toxicity and higher safety, and is useful as a drug for prevention or suppression of rejection of organs or bone marrow transplantation, or as a drug for prevention or treatment of various autoimmune diseases or allergic diseases.