7618-03-3

Basic information

• Product Name: benzyl<18F>fluoride
• Synonyms: benzyl<18F>fluoride
• CAS NO: 7618-03-3
• Molecular Weight: 109.133
• Mol File: 7618-03-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: benzyl<18F>fluoride(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl<18F>fluoride(7618-03-3)
• EPA Substance Registry System: benzyl<18F>fluoride(7618-03-3)

Safety Data

• Hazardous Substances Data: 7618-03-3(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 1024-41-5 benzyl tosylate 
• 1240423-59-9 benzyl 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecane-1-sulfonate 
• 1054554-28-7 benzyl pentafluorobenzenesulfonate 

Relevant articles and documents

Titania-catalyzed radiofluorination of tosylated precursors in highly aqueous medium

Nucleophilic radiofluorination is an efficient synthetic route to many positron-emission tomography (PET) probes, but removal of water to activate the cyclotron-produced [18F]fluoride has to be performed prior to reaction, which significantly increases overall radiolabeling time and causes radioactivity loss. In this report, we demonstrate the possibility of 18F-radiofluorination in highly aqueous medium. The method utilizes titania nanoparticles, 1:1 (v/v) acetonitrile-thexyl alcohol solvent mixture, and tetra-n-butylammonium bicarbonate as a phase-transfer agent. Efficient radiolabeling is directly performed with aqueous [18F]fluoride without the need for a drying/azeotroping step to significantly reduce radiosynthesis time. High radiochemical purity of the target compound is also achieved. The substrate scope of the synthetic strategy is demonstrated with a range of aromatic, aliphatic, and cycloaliphatic tosylated precursors.

Use of perfluoro groups in nucleophilic 18F-fluorination

Substrates with leaving groups that contained perfluoro moieties were investigated in labelling chemistry in order to exploit their properties to improve reactivity and purification. [18F](Fluoromethyl)benzene was used as the model target compound. Precursors containing perfluoroalkyl and perfluoroaryl sulfonate moieties were subjected to nucleophilic 18F-fluorination, and the impact of perfluoro groups on the substitution reaction and product purification was investigated. [ 18F]Fluoride interacted with perfluoroalkyl chains, precluding nucleophilic substitution. When perfluoroaryl groups were used, the substitution proceeded, and the separation of product was explored. The radiolabelled product was obtained in 32% analytical yield and the radiochemical purity was increased to approximately 77% using fluorous solid phase extraction purification. Copyright