76182-48-4Relevant articles and documents
Fused bicyclic carboxamide derivatives and methods of their use
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Page/Page column 48, (2010/02/11)
Fused bicyclic carboxamide derivatives are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed.
Discovery of a new class of potent, selective, and orally active prostaglandin D2 receptor antagonists
Torisu, Kazuhiko,Kobayashi, Kaoru,Iwahashi, Maki,Nakai, Yoshihiko,Onoda, Takahiro,Nagase, Toshihiko,Sugimoto, Isamu,Okada, Yutaka,Matsumoto, Ryoji,Nanbu, Fumio,Ohuchida, Shuichi,Nakai, Hisao,Toda, Masaaki
, p. 5361 - 5378 (2007/10/03)
N-(p-Alkoxy)benzoyl-2-methylindole-4-acetic acids 2r and 2s were identified as a new class of orally active prostaglandin D2 (PGD2) receptor antagonists. The process of discovering a series of N-(p-alkoxy)benzoyl-2-methylindole-4-ace
Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
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, (2008/06/13)
Benzo-fused heterocyclic compounds having a 5-membered ring, processes for their preperation, their use as medicaments, their use as diagnostic agents and medicaments containing them. Benzo-fused heterocyclic compounds having a 5-membered ring, of the formula I STR1 where X is N or CR(6); Y is oxygen, S or NR(7); A and B together are a bond or are both hydrogen, if, at the same time, X is CR(6) and Y is NR(7), one of the substituents R(1) to R(6) is a --CO--N=C(NH2)2 group; the other respective substituents R(1) to R(6) are H, Hal or alkyl; up to two of the other substituents R(1) to R(6) are CN, NO2, N3, (C1 -C4)-alkoxy, CF3 ; up to one of the other substituents is R(8)--Cn H2n --Z-- or phenyl; R(7) is H, alk(en)yl or R(8)--Cn H2n --, and pharmaceutically tolerated salts there of, are described. A process f or the preparation of the compounds I which comprises reacting a compound of the formula II STR2 in which one of the substituents R(1)' to R(5)' is a --CO--L group and L is a leaving group which can easily be replaced nucleophilically, with guanidine, and, if appropriate, converting the product into the pharmacologically tolerated salt, furthermore is also described.
Heterocyclic compounds having anti-diabetic activity and their use
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, (2008/06/13)
Compounds of formula (I): STR1 [wherein: X represents an unsubstituted or substituted indolyl, indolinyl, azaindolyl, azaindolinyl, imidazopyridyl or imidazopyrimidinyl group; Y represents an oxygen or sulfur atom; Z represents a 2,4-dioxothiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxooxadiazolidin-2-ylmethyl or N-hydroxyureidomethyl group; R represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxy group, a nitro group, an aralkyl group or a unsubstituted or substituted amino group; and m is an integer of from 1 to 5] have hypoglycemic and anti-diabetic activities.
HETEROATOM DIRECTED PHOTOARYLATION. SYNTHESIS OF FUNCTIONALIZED INDOLINES
Schultz, Authur G.,Sha, Chin-Kang
, p. 1757 - 1761 (2007/10/02)
The photochemical syntheses of indolines 25-28 are described.
