76189-53-2Relevant academic research and scientific papers
A NOVEL SYNTHESIS OF THE CARBAPEN-2-EM DERIVATIVES
Hatanaka, Minoru,Yamamoto, Yu-ichi,Nitta, Hajime,Ishimaru, Toshiyasu
, p. 3883 - 3886 (2007/10/02)
A new synthesis of the carbapen-2-em ring system, the basic nucleus of thienamycin and its relatives, is described.
A FACILE SYNTHESIS OF BENZYL 3,7-DIOXO-1-AZABICYCLOHEPTANE-2-CARBOXYLATE. A POTENTIAL PRECURSOR OF THIENAMYCIN AND CLAVULANIC ACID ANALOGS
Berges, D. A.,Snipes, E. R.,Chan, G. W.,Kingsbury, W. D.,Kinzig, C. M.
, p. 3557 - 3560 (2007/10/02)
A novel, high yield synthesis of the 1-carbapenam ring system 3 is described in which the entire carbon framework is introduced in a single step from simple precursors.
A novel synthesis of the carbapen-2-em ring system
Ratcliffe,Salzmann,Christensen
, p. 31 - 34 (2007/10/02)
A new synthesis of the carbapenem ring system, as found in thienamycin and related natural products, has been developed. The key step involves a highly efficient carbene insertion reaction which produces the bicyclic ring system by forming the N3 bond.
SYNTHETIC STUDIES ON OPTICALLY ACTIVE β-LACTAMS. CHIRAL SYNTHESIS OF CARBAPENAM RING SYSTEM STARTING FROM L-ASPARTIC ACID
Ikota, Nobuo,Shibata, Hisanari,Koga, Kenji
, p. 1077 - 1080 (2007/10/02)
Benzyl (3R,5R)-1-carba-2-oxopenam-3-carboxylate (12), a useful synthon for β-lactams having carbapenem ring system, was synthesized in optically pure state starting from L-aspartic acid.
